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33 Article(s) on File
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P53 Mutations Change Phosphatidylinositol Acyl Chain Composition
Naguib A,
Bencze G,
Engle DD,
Chio ,
Herzka T,
Watrud K,
Bencze S,
Tuveson DA,
Pappin DJ,
Trotman LC

Cell Reports
  (0): Dec 24 2014   Nlm
[Abstract]
[DOI] [Full Text]

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output
Reyes G,
Niederst M,
Cohen-Katsenelson K,
Stender JD,
Kunkel MT,
Chen M,
Brognard J,
Sierecki E,
Gao T,
Nowak DG,
Trotman LC,
Glass CK,
Newton AC

Proceedings of the National Academy of Sciences of the United States of America
  111 (38): E3957-E3965; Sep 23 2014   Nlm
[Abstract]
[DOI] [Full Text]

A Unified Nomenclature and Amino Acid Numbering for Human PTEN
Pulido R,
Baker SJ,
Barata JT,
Carracedo A,
Cid VJ,
Chin-Sang ID,
Dave V,
den Hertog J,
Devreotes P,
Eickholt BJ,
Eng C,
Furnari FB,
Georgescu MM,
Gericke A,
Hopkins B,
Jiang X,
Lee SR,
Losche M,
Malaney P,
Matias-Guiu X,
Molina M,
Pandolfi PP,
Parsons R,
Pinton P,
Rivas C,
Rocha RM,
Rodriguez MS,
Ross AH,
Serrano M,
Stambolic V,
Stiles B,
Suzuki A,
Tan SS,
Tonks NK,
Trotman LC,
Wolff N,
Woscholski R,
Wu H,
Leslie NR

Science signaling
  7 (332): pe15; Jul 1 2014   Nlm
[Abstract]
[DOI] [Full Text]

Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy
Chen M,
Nowak DG,
Trotman LC

Clinical Cancer Research
  20 (12): 3057-3063; Jun 15 2014   NLM
[Abstract]
[DOI] [Full Text]

Molecular Pathways: PI3K Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy
Chen M,
Nowak DG,
Trotman LC

Clin Cancer Res
  20 (12): 3057-63; Jun 15 2014   NLM
[Abstract]
[DOI] [Full Text]

RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis
Cho H,
Herzka T,
Zheng W,
Qi J,
Wilkinson JE,
Bradner JE,
Robinson BD,
Castillo-Martin M,
Cordon-Cardo C,
Trotman LC

Cancer Discovery
  4 (3): 318-33; Mar 2014   Nlm
[Abstract]
[DOI] [Full Text]

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors
Labbé DP,
Nowak DG,
Deblois G,
Lessard L,
Giguère V,
Trotman LC,
Tremblay ML

Molecular Cancer Research
  12 (2): 184-189; Feb 2014  
[Abstract]
[DOI] [Full Text]

RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten-mutant metastasis
Cho H,
Herzka T,
Zheng W,
Qi J,
Wilkinson JE,
Bradner JE,
Robinson BD,
Castillo-Martin M,
Cordon-Cardo C,
Trotman LC

Cancer Discov
  (0): Jan 27 2014   Nlm
[Abstract]
[DOI] [Full Text]

PTEN plasticity: how the taming of a lethal gene can go too far
Naguib A,
Trotman LC

Trends in Cell Biology
  23 (8): 374-379; Apr 9 2013   NLM
[Abstract]
[DOI] [Full Text]

PTEN levels are controlled by a nuclear transport receptor in lung cancer
Chen MH,
Herzka TM,
Zeeman ME,
Plafker KS,
Minderer M,
Castillo-Martin M,
Cordon-Cardo C,
Plafker SM,
Trotman LC

Cancer Research
  73 (8): 5258; Apr 2013  
[Abstract]
[DOI] [Full Text]

Rapid Cap: A new generation of mouse models for prostate cancer
Cho HJ,
Herzka T,
Zheng W,
Castillo-Martin M,
Cordon-Cardo C,
Trotman LC

Cancer Research
  73 (8): 4091; Apr 2013  
[Abstract]
[DOI] [Full Text]

Upstream activation of PTEN
Naguib A,
Bencze G,
Faehnle CR,
Schalch T,
Lazar Z,
Ruse CI,
Joshua-Tor L,
Pappin DJ,
Trotman LC

Cancer Research
  73 (8): 5156; Apr 2013  
[Abstract]
[DOI] [Full Text]

PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer
Lessard L,
Labbé DP,
Deblois G,
Beǵin LR,
Hardy S,
Mes-Masson AM,
Saad F,
Trotman LC,
Giguére V,
Tremblay ML

Cancer Research
  72 (6): 1529-1537; Mar 15 2012  
[Abstract]
[DOI] [Full Text]

PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex
Xiong Q,
Oviedo HV,
Trotman LC,
Zador AM

J Neurosci
  32 (5): 1643-52; Feb 1 2012   NLM
[Abstract]
[DOI] [Full Text]

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Howitt J,
Lackovic J,
Low LH,
Naguib A,
Macintyre A,
Goh CP,
Callaway JK,
Hammond V,
Thomas T,
Dixon M,
Putz U,
Silke J,
Bartlett P,
Yang BL,
Kumar S,
Trotman LC,
Tan SS

Journal of Cell Biology
  196 (1): 29-36; Jan 2012  
[Abstract]
[DOI] [Full Text]

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
Chen MH,
Pratt CP,
Zeeman ME,
Schultz N,
Taylor BS,
ONeill A,
Castillo-Martin M,
Nowak DG,
Naguib A,
Grace DM,
Murn J,
Navin N,
Atwal GS,
Sander C,
Gerald WL,
Cordon-Cardo C,
Newton AC,
Carver BS,
Trotman LC

Cancer Cell
  20 (2): 173-186; Aug 2011   PMC3176728
[Abstract]
[DOI] [Full Text]

Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era.
Trotman LC

Molecular Biology of the Cell
  22 (6): Mar 2011   PMC3057687
[DOI]

Towards patient-based cancer therapeutics
Schreiber SL,
Shamji AF,
Clemons PA,
Hon C,
Koehler AN,
Munoz B,
Palmer M,
Stern AM,
Wagner BK,
Powers S,
Lowe SW,
Guo X,
Krasnitz A,
Sawey ET,
Sordella R,
Stein LD,
Trotman LC,
Califano A,
Dalla-Favera R,
Ferrando A,
Iavarone A,
Pasqualucci L,
Silva J,
Stockwell BR,
Hahn WC,
Chin L,
DePinho RA,
Boehm JS,
Gopal S,
Huang A,
Root DE,
Weir BA,
Gerhard DS,
Zenklusen JC,
Roth MG,
White MA,
Minna JD,
MacMillan JB,
Posner BA

Nature Biotechnology
  28 (9): 904-906; Sep 2010   PMCID: PMC2939009
[DOI] [Full Text] [PDF]

New views into the prostate cancer genome
Trotman LC,
Powers S

Cancer Cell
  18 (1): 1-2; Jul 13 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Subtle variations in Pten dose determine cancer susceptibility
Alimonti A,
Carracedo A,
Clohessy JG,
Trotman LC,
Nardella C,
Egia A,
Salmena L,
Sampieri K,
Haveman WJ,
Brogi E,
Richardson AL,
Zhang J,
Pandolfi PP

Nature Genetics
  42 (5): 454-458; May 2010   PMC3118559
[Abstract]
[DOI] [Full Text] [PDF]

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Alimonti A,
Nardella C,
Chen Z,
Clohessy JG,
Carracedo A,
Trotman LC,
Cheng K,
Varmeh S,
Kozma SC,
Thomas G,
Rosivatz E,
Woscholski R,
Cognetti F,
Scher HI,
Pandolfi PP

Journal of Clinical Investigation
  120 (3): 681-693; Mar 2010  
[Abstract]
[DOI] [Full Text]

PTEN
Trotman LC
In:
Handbook of Cell Signaling (Second Edition)
(eds. Ralph, A. Bradshaw Edward, A. Dennis) San Diego: Academic Press; 2010. : 849-854  
[DOI] [Full Text]

The Effect of Deleting p110{delta} on the Phenotype and Function of PTEN-Deficient B Cells
Janas ML,
Hodson D,
Stamataki Z,
Hill S,
Welch K,
Gambardella L,
Trotman LC,
Pandolfi PP,
Vigorito E,
Turner M

J Immunol
  180 (2): 739-46; Jan 15 2008  
[Abstract]
[Full Text] [PDF]

Ubiquitination regulates PTEN nuclear import and tumor suppression
Trotman LC,
Wang X,
Alimonti A,
Chen Z,
Teruya-Feldstein J,
Yang H,
Pavletich NP,
Carver BS,
Cordon-Cardo C,
Erdjument-Bromage H,
Tempst P,
Chi SG,
Kim HJ,
Misteli T,
Jiang X,
Pandolfi PP

Cell
  128 (1): 141-56; Jan 12 2007   PMCID: PMC1855245
[Abstract]
[DOI] [Full Text] [PDF]

NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN
Wang X,
Trotman LC,
Koppie T,
Alimonti A,
Chen Z,
Gao Z,
Wang J,
Erdjument-Bromage H,
Tempst P,
Cordon-Cardo C,
Pandolfi PP,
Jiang X

Cell
  128 (1): 129-139; Jan 2007  
[Abstract]
[DOI] [Full Text]

Identification of a tumour suppressor network opposing nuclear Akt function
Trotman LC,
Alimonti A,
Scaglioni PP,
Koutcher JA,
Cordon-Cardo C,
Pandolfi PP

Nature
  441 (7092): 523-527; May 25 2006  
[Abstract]
[DOI] [Full Text]

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen Z,
Trotman LC,
Shaffer D,
Lin HK,
Dotan ZA,
Niki M,
Koutcher JA,
Scher HI,
Ludwig T,
Gerald W,
Cordon-Cardo C,
Pandolfi PP

Nature
  436 (7051): 725-30; Aug 4 2005   NLM
[Abstract]
[DOI] [Full Text]

Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export
Strunze S,
Trotman LC,
Boucke K,
Greber UF

Molecular Biology of the Cell
  16 (6): 2999-3009; 2005  
[Abstract]
[DOI] [Full Text]

SUMO Modification of Huntingtin and Huntingtons Disease Pathology
Steffan JS,
Agrawal N,
Pallos J,
Rockabrand E,
Trotman LC,
Slepko N,
Illes K,
Lukacsovich T,
Zhu YZ,
Cattaneo E,
Pandolfi PP,
Thompson LM,
Marsh JL

Science
  304 (5667): 100-104; Apr 2 2004  
[Abstract]
[DOI]

Non-classical export of a adenovirus structural protein
Trotman LC,
Achermann DP,
Keller S,
Straub M,
Greber UF

Traffic
  4 (6): 390-402; Jun 2003  
[Abstract]
[DOI] [Full Text]

PTEN and p53: who will get the upper hand?
Trotman LC,
Pandolfi PP

Cancer Cell
  3 (2): 97-9; Feb 2003   NLM
[Full Text]

Pten dose dictates cancer progression in the prostate
Trotman LC,
Niki M,
Dotan ZA,
Koutcher JA,
Di Cristofano A,
Xiao A,
Khoo AS,
Roy-Burman P,
Greenberg NM,
Van Dyke T,
Cordon-Cardo C,
Pandolfi PP

Plos Biology
  1 (3): 2003  
[Abstract]
[DOI] [Full Text]

Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
Trotman LC,
Mosberger N,
Fornerod M,
Stidwill RP,
Greber UF

Nature Cell Biology
  3 (12): 1092-1100; 2001  
[Abstract]
[DOI] [Full Text]


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