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14 Article(s) on File
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The mechanisms behind the therapeutic activity of BET bromodomain inhibition
Shi J,
Vakoc CR

Mol Cell
  54 (5): 728-36; Jun 5 2014   Nlm
[Abstract]
[DOI] [Full Text]

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Shi J,
Vakoc C

Molecular Cell
  54 (5): 728-736; Jun 5 2014   NLM
[Abstract]
[DOI] [Full Text]

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Shi J,
Whyte WA,
Zepeda-Mendoza CJ,
Milazzo JP,
Shen C,
Roe JS,
Minder JL,
Mercan F,
Wang E,
Eckersley-Maslin MA,
Campbell AE,
Kawaoka S,
Shareef S,
Zhu Z,
Kendall J,
Muhar M,
Haslinger C,
Yu M,
Roeder RG,
Wigler MA,
Blobel GA,
Zuber J,
Spector DL,
Young RA,
Vakoc CR

Genes Dev
  27 (24): 264-273 ; Nov 27 2013   NLM
[Abstract]
[DOI] [Full Text]

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
Wang E,
Kawaoka S,
Yu M,
Shi J,
Ni T,
Yang W,
Zhu J,
Roeder RG,
Vakoc CR

Proc Natl Acad Sci U S A
  110 (10): 3901-6; Mar 5 2013   Nlm
[Abstract]
[DOI] [Full Text]

Implication of a Rare Deletion at Distal 16p11.2 in Schizophrenia
Guha S,
Rees E,
Darvasi A,
Ivanov D,
Ikeda M,
Bergen SE,
Magnusson PK,
Cormican P,
Morris D,
Gill M,
Cichon S,
Rosenfeld JA,
Lee A,
Gregersen PK,
Kane JM,
Malhotra AK,
Rietschel M,
Nothen MM,
Degenhardt F,
Priebe L,
Breuer R,
Strohmaier J,
Ruderfer DM,
Moran JL,
Chambert KD,
Sanders AR,
Shi JX,
Kendler K,
Riley B,
ONeill T,
Walsh D,
Malhotra D,
Corvin A,
Purcell S,
Sklar P,
Iwata N,
Hultman CM,
Sullivan PF,
Sebat J,
McCarthy S,
Gejman PV,
Levinson DF,
Owen MJ,
ODonovan MC,
Lencz T,
Kirov G

Jama Psychiatry
  70 (3): 253-260; Mar 2013  
[Abstract]
[DOI] [Full Text]

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia
Shi J,
Wang E,
Zuber J,
Rappaport A,
Taylor M,
Johns C,
Lowe SW,
Vakoc CR

Oncogene
  32 (7): 930-938; Feb 2 2013   NLM
[Abstract]
[DOI] [Full Text]

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)
Herrmann H,
Blatt K,
Shi J,
Gleixner KV,
Cerny-Reiterer S,
Müllauer L,
Vakoc CR,
Sperr WR,
Horny HP,
Bradner JE,
Zuber J,
Valent P

Oncotarget
  3 (12): 1588-1599; Dec 2012  
[Abstract]
[Full Text]

Inhibition of c-Myc Expression and Function in Hematologic Malignancies
Issa GC,
Delmore JE,
McKeown MR,
Lemieux ME,
Rahl PB,
Jacobs HM,
Kastritis E,
Gilpatrick T,
Paranal RM,
Qi J,
Shi JW,
Chesi M,
Schinzel AC,
Vakoc CR,
Bergsagel PL,
Richardson PG,
Young R,
Hahn WC,
Ghobrial IM,
Anderson KC,
Kung AL,
Mitsiades CS,
Bradner JE

Blood
  118 (21): 613-614; Nov 2011  
[Full Text]

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML
Herrmann H,
Blatt K,
Shi JW,
Rappaport AR,
Gleixner KV,
Cerny-Reiterer S,
Peter B,
Wang E,
Sperr WR,
Bradner JE,
Lowe SW,
Vakoc CR,
Zuber J,
Valent P

Blood
  118 (21): 1487-1487; Nov 2011  
[Full Text]

BET bromodomain inhibition as a therapeutic strategy to target c-Myc
Delmore JE,
Issa GC,
Lemieux ME,
Rahl PB,
Shi J,
Jacobs HM,
Kastritis E,
Gilpatrick T,
Paranal RM,
Qi J,
Chesi M,
Schinzel AC,
McKeown MR,
Heffernan TP,
Vakoc CR,
Bergsagel PL,
Ghobrial IM,
Richardson PG,
Young RA,
Hahn WC,
Anderson KC,
Kung AL,
Bradner JE,
Mitsiades CS

Cell
  146 (6): 904-917; Sep 16 2011   PMC3187920
[Abstract]
[DOI] [Full Text]

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber J,
Shi J,
Wang E,
Rappaport AR,
Herrmann H,
Sison EA,
Magoon D,
Qi J,
Blatt K,
Wunderlich M,
Taylor MJ,
Johns C,
Chicas A,
Mulloy JC,
Kogan SC,
Brown P,
Valent P,
Bradner JE,
Lowe SW,
Vakoc CR

Nature
  478 (7370): 524-528; Aug 3 2011   NLM
[Abstract]
[DOI]

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
Zuber J,
Rappaport AR,
Luo W,
Wang E,
Chen C,
Vaseva AV,
Shi J,
Weissmueller S,
Fellman C,
Taylor MJ,
Weissenboeck M,
Graeber TG,
Kogan SC,
Vakoc CR,
Lowe SW

Genes Dev
  25 (15): 1628-1640; Aug 1 2011  
[Abstract]
[DOI]

An RNA1 Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL AF9 Leukemia From Normal Hematopoietic Cells
Vakoc CR,
Zuber J,
Lowe S,
Wang E,
Rappaport AR,
Shi JW

Blood
  116 (21): 35-35; Nov 2010   ISI


Single nucleotide polymorphism discovery in candidate genes for rheumatoid arthritis
Hacker C,
Thomas D,
Doshi J,
Kimberly RP,
Gingeras TR,
Patil N

American Journal of Human Genetics
  67 (4): 335-335; Oct 2000  



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