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18 Article(s) on File
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Identifying disease mutations in genomic medicine settings: current challenges and how to accelerate progress
Lyon GJ,
Wang K

Genome Med
  4 (7): 58-58; Jul 2012  
[Abstract]
[DOI] [Full Text]

SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data
Wei Z,
Wang W,
Hu P,
Lyon GJ,
Hakonarson H

Nucleic Acids Res
  39 (19): e132; Oct 2011  
[Abstract]
[DOI] [Full Text]

Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency
Rope AF,
Wang K,
Evjenth R,
Xing J,
Johnston JJ,
Swensen JJ,
Johnson WE,
Moore B,
Huff CD,
Bird LM,
Carey JC,
Opitz JM,
Stevens CA,
Jiang T,
Schank C,
Fain HD,
Robison R,
Dalley B,
Chin S,
South ST,
Pysher TJ,
Jorde LB,
Hakonarson H,
Lillehaug JR,
Biesecker LG,
Yandell M,
Arnesen T,
Lyon GJ

Am J Hum Genet
  89 (1): 28-43; Jul 15 2011  
[Abstract]
[DOI] [Full Text]

Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications
Lyon GJ,
Jiang T,
Van Wijk R,
Wang W,
Bodily PM,
Xing J,
Tian L,
Robison RJ,
Clement M,
Lin Y,
Zhang P,
Liu Y,
Moore B,
Glessner JT,
Elia J,
Reimherr F,
van Solinge WW,
Yandell M,
Hakonarson H,
Wang J,
Johnson WE,
Wei Z,
Wang K

Discov Med
  12 (62): 41-55; Jul 2011  
[Abstract]


Presynaptic regulation of dopamine transmission in schizophrenia
Lyon GJ,
Abi-Dargham A,
Moore H,
Lieberman JA,
Javitch JA,
Sulzer D

Schizophr Bull
  37 (1): 108-117; Jan 2011  
[Abstract]
[DOI] [Full Text]

Personal account of the discovery of a new disease using next-generation sequencing. Interview by Natalie Harrison
Lyon GJ

Pharmacogenomics
  12 (11): 1519-1523; Jan 2011  
[DOI] [Full Text]

Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourettes disorder
Lyon GJ,
Samar SM,
Conelea C,
Trujillo MR,
Lipinski CM,
Bauer CC,
Brandt BC,
Kemp JJ,
Lawrence ZE,
Howard J,
Castellanos FX,
Woods D,
Coffey BJ

J Child Adolesc Psychopharmacol
  20 (4): 283-289; 2010  
[Abstract]
[DOI] [Full Text]

Tourettes Disorder
Lyon GJ,
Shprecher D,
Coffey B,
Kurlan R

Curr Treat Options Neurol
  12 (4): 274-286; 2010  
[Abstract]
[DOI] [Full Text]

Aripiprazole in children and adolescents with Tourettes disorder: an open-label safety and tolerability study
Lyon GJ,
Samar S,
Jummani R,
Hirsch S,
Spirgel A,
Goldman R,
Coffey BJ

J Child Adolesc Psychopharmacol
  19 (6): 623-633; 2009  
[Abstract]
[DOI] [Full Text]

Postraumatic stress disorder and reactive attachment disorder: outcome in an adolescent
Lyon GJ,
Coffey B,
Silva R

J Child Adolesc Psychopharmacol
  18 (6): 641-646; 2008  
[DOI] [Full Text]

Possible varenicline-induced paranoia and irritability in a patient with major depressive disorder, borderline personality disorder, and methamphetamine abuse in remission
Lyon GJ

J Clin Psychopharmacol
  28 (6): 720-721; 2008  
[DOI] [Full Text]

Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing
Wright JS,
Lyon GJ,
George EA,
Muir TW,
Novick RP

Proc Natl Acad Sci U S A
  101 (46): 16168-16173; 2004  
[Abstract]
[DOI] [Full Text]

Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria
Lyon GJ,
Novick RP

Peptides
  25 (9): 1389-1403; 2004  
[Abstract]
[DOI] [Full Text]

Chemical signaling among bacteria and its inhibition
Lyon GJ,
Muir TW

Chem Biol
  10 (11): 1007-1021; 2003  
[Abstract]
[DOI] [Full Text]

Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry
Kalkum M,
Lyon GJ,
Chait BT

Proc Natl Acad Sci U S A
  100 (5): 2795-2800; 2003  
[Abstract]
[DOI] [Full Text]

Toward fully synthetic N-linked glycoproteins
Miller JS,
Dudkin VY,
Lyon GJ,
Muir TW,
Danishefsky SJ

Angew Chem Int Ed Engl
  42 (4): 431-434; 2003  
[DOI] [Full Text]

Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus
Lyon GJ,
Wright JS,
Muir TW,
Novick RP

Biochemistry
  41 (31): 10095-10104; 2002  
[Abstract]
[DOI] [Full Text]

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling
Lyon GJ,
Wright JS,
Christopoulos A,
Novick RP,
Muir TW

J Biol Chem
  277 (8): 6247-6253; 2002  
[Abstract]
[DOI] [Full Text]


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