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191 Article(s) on File
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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Rudalska R,
Dauch D,
Longerich T,
McJunkin K,
Wuestefeld T,
Kang TW,
Hohmeyer A,
Pesic M,
Leibold J,
von Thun A,
Schirmacher P,
Zuber J,
Weiss KH,
Powers S,
Malek NP,
Eilers M,
Sipos B,
Lowe SW,
Geffers R,
Laufer S,
Zender L

Nature Medicine
  20 (10): 1138-1146; Oct 2014   NLM
[Abstract]
[DOI] [Full Text]

Development of siRNA payloads to target KRAS-mutant cancer
Yuan TL,
Fellmann C,
Lee CS,
Ritchie CD,
Thapar V,
Lee LC,
Hsu DJ,
Grace D,
Carver JO,
Zuber J,
Luo J,
McCormick F,
Lowe SW

Cancer Discovery
  4 (10): 1182; Oct 1 2014   Nlm
[Abstract]
[DOI] [Full Text]

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
Bolden JE,
Tasdemir N,
Dow LE,
van Es JH,
Wilkinson JE,
Zhao Z,
Clevers H,
Lowe SW

Cell Rep
  8 (6): 1919-1929; Sep 25 2014   Nlm
[Abstract]
[DOI] [Full Text]

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
Huang CH,
Lujambio A,
Zuber J,
Tschaharganeh DF,
Doran MG,
Evans MJ,
Kitzing T,
Zhu N,
de Stanchina E,
Sawyers CL,
Armstrong SA,
Lewis JS,
Sherr CJ,
Lowe SW

Genes and Development
  28 (16): 1800-1814; Aug 15 2014   NLM
[Abstract]
[DOI] [Full Text]

p53Psi is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state
Senturk S,
Yao Z,
Camiolo M,
Stiles B,
Rathod T,
Walsh AM,
Nemajerova A,
Lazzara MJ,
Altorki NK,
Krainer A,
Moll UM,
Lowe SW,
Cartegni L,
Sordella R

Proceedings of the National Academy of Sciences of the United States of America
  111 (32): E3287-E3296; Aug 12 2014   Nlm
[Abstract]
[DOI] [Full Text]

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer
Tschaharganeh DF,
Xue W,
Calvisi DF,
Evert M,
Michurina TV,
Dow LE,
Banito A,
Katz SF,
Kastenhuber ER,
Weissmueller S,
Huang CH,
Lechel A,
Andersen JB,
Capper D,
Zender L,
Longerich T,
Enikolopov G,
Lowe SW

Cell
  158 (3): 579-92; Jul 31 2014   Nlm
[Abstract]
[DOI] [Full Text]

A common functional consequence of tumor-derived mutations within c-MYC
Chakraborty AA,
Scuoppo C,
Dey S,
Thomas LR,
Lorey SL,
Lowe SW,
Tansey WP

Oncogene
  (0): Jul 7 2014   Nlm
[Abstract]
[DOI] [Full Text]

Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference
Zaiss AK,
Zuber J,
Chu C,
Machado HB,
Jiao J,
Catapang AB,
Ishikawa TO,
Gil JS,
Lowe SW,
Herschman HR

PLoS One
  9 (7): e101263; Jul 2 2014   Nlm
[Abstract]
[DOI] [Full Text]

Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5
Mazurek A,
Park Y,
Miething C,
Wilkinson JE,
Gillis J,
Lowe S,
Vakoc C,
Stillman B

Cell Reports
  7 (6): 18887-1899; Jun 26 2014   NLM
[Abstract]
[DOI] [Full Text]

PTEN action in leukaemia dictated by the tissue microenvironment
Miething C,
Scuoppo C,
Bosbach B,
Appelmann I,
Nakitandwe J,
Ma J,
Wu G,
Lintault L,
Auer M,
Premsrirut PK,
Teruya-Feldstein J,
Hicks J,
Benveniste H,
Speicher MR,
Downing JR,
Lowe SW

Nature
  510 (7505): 402-406; May 4 2014   NLM
[Abstract]
[DOI] [Full Text]

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia
Chen C,
Liu Y,
Rappaport AR,
Kitzing T,
Schultz N,
Zhao Z,
Shroff AS,
Dickins RA,
Vakoc CR,
Bradner JE,
Stock W,
LeBeau MM,
Shannon KM,
Kogan S,
Zuber J,
Lowe SW

Cancer Cell
  25 (5): 652-65; May 1 2014   Nlm
[Abstract]
[DOI] [Full Text]

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Chen C,
Liu Y,
Rappaport AR,
Kitzing T,
Schultz N,
Zhao Z,
Shroff AS,
Dickins RA,
Vakoc CR,
Bradner JE,
Stock W,
Lebeau MM,
Shannon KM,
Kogan S,
Zuber J,
Lowe SW

Cancer Cell
  25 (5): 652-665; Apr 30 2014   NLM
[Abstract]
[DOI] [Full Text]

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice
Dow LE,
Nasr Z,
Saborowski M,
Ebbesen SH,
Manchado E,
Tasdemir N,
Lee T,
Pelletier J,
Lowe SW

PLoS ONE
  9 (4): e95236; Apr 17 2014   NLM
[Abstract]
[DOI] [Full Text]

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
Lito P,
Saborowski A,
Yue J,
Solomon M,
Joseph E,
Gadal S,
Saborowski M,
Kastenhuber E,
Fellmann C,
Ohara K,
Morikami K,
Miura T,
Lukacs C,
Ishii N,
Lowe S,
Rosen N

Cancer Cell
  25 (5): 697-710; Apr 15 2014   NLM
[Abstract]
[DOI] [Full Text]

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor beta Signaling
Weissmueller S,
Manchado E,
Saborowski M,
Morris JP,
Wagenblast E,
Davis CA,
Moon SH,
Pfister NT,
Tschaharganeh DF,
Kitzing T,
Aust D,
Markert EK,
Wu J,
Grimmond SM,
Pilarsky C,
Prives C,
Biankin AV,
Lowe SW

Cell
  157 (2): 382-94; Apr 10 2014   NLM
[Abstract]
[DOI] [Full Text]

Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target
Saborowski A,
Saborowski M,
Davare MA,
Druker BJ,
Klimstra DS,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  110 (48): 19513-19518; Nov 2013  
[Abstract]
[DOI] [Full Text]

Two Distinct Categories of Focal Deletions in Cancer Genomes
Rajaram M,
Zhang J,
Wang T,
Li J,
Kuscu C,
Qi H,
Kato M,
Grubor V,
Weil RJ,
Helland A,
Borrenson-Dale AL,
Cho KR,
Levine DA,
Houghton AN,
Wolchok JD,
Myeroff L,
Markowitz SD,
Lowe SW,
Zhang M,
Krasnitz A,
Lucito R,
Mu D,
Powers RS

PLoS ONE
  8 (6): e66264; Jun 21 2013   NLM
[Abstract]
[DOI] [Full Text]

Senescent cells spread the word: non-cell autonomous propagation of cellular senescence
Tasdemir N,
Lowe SW

Embo J
  84 (1): 114-127; Jun 18 2013   NLM
[DOI] [Full Text]

RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an E mu-myc/Bcl-2 mouse model
Mills JR,
Malina A,
Lee T,
Di Paola D,
Larsson O,
Miething C,
Grosse F,
Tang HL,
Zannis-Hadjopoulos M,
Lowe SW,
Pelletier J

Blood
  121 (17): 3402-3412; Apr 25 2013   NLM
[DOI] [Full Text]

Granule exocytosis mediates immune surveillance of senescent cells
Sagiv A,
Biran A,
Yon M,
Simon J,
Lowe SW,
Krizhanovsky V

Oncogene
  32 (15): 1971-7; Apr 11 2013   Nlm
[Abstract]
[DOI] [Full Text]

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia
Shi J,
Wang E,
Zuber J,
Rappaport A,
Taylor M,
Johns C,
Lowe SW,
Vakoc CR

Oncogene
  32 (7): 930-938; Feb 2 2013   NLM
[Abstract]
[DOI] [Full Text]

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence
Wall M,
Poortinga G,
Stanley KL,
Lindemann RK,
Bots M,
Chan CJ,
Bywater MJ,
Kinross KM,
Astle MV,
Waldeck K,
Hannan KM,
Shortt J,
Smyth MJ,
Lowe SW,
Hannan RD,
Pearson RB,
Johnstone RW,
McArthur GA

Cancer Discovery
  3 (1): 82-95; Jan 2013  
[DOI] [Full Text]

Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Dow L,
Lowe S,
Zuber J,
Hannon G

European Journal of Cancer
  48 (0): 16-16; Nov 6 2012  
[Full Text]

An oncogenome-based RNAi screen identifies a tumour suppressor network in B-cell lymphoma relying on the polyamine-hypusine axis
Miething C,
Scuoppo C,
Lindqvist L,
Reyes J,
Ruse C,
Appelmann I,
Yoon S,
Krasnitz A,
Teruya-Feldstein J,
Pappin D,
Pelletier J,
Lowe S

Onkologie
  35 (0): 104-104; Oct 6 2012  
[Full Text]

PTEN affects T-cell dissemination and survival in a murine model of T-cell lymphoma
Miething C,
Scuoppo C,
Premsrirut P,
Hicks J,
Lowe S

Onkologie
  35 (0): 6-6; Oct 2012  
[Full Text]

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation
Chandra T,
Kirschner K,
Thuret J,
Pope B,
Ryba T,
Newman S,
Ahmed K,
Samarajiwa S,
Salama R,
Carroll T,
Stark R,
Janky R,
Narita M,
Xue L,
Chicas A,
Nũnez S,
Janknecht R,
Hayashi-Takanaka Y,
Wilson M,
Marshall A,
Odom D,
Babu M,
Bazett-Jones D,
Tavaré S,
Edwards PW,
Lowe S,
Kimura H,
Gilbert D

Molecular Cell
  47 (2): 203-214; Jul 27 2012  
[Abstract]
[DOI] [Full Text]

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
Aksoy O,
Chicas A,
Zeng T,
Zhao Z,
McCurrach M,
Wang X,
Lowe SW

Genes Dev
  26 (14): 1546-57; Jul 15 2012   Nlm
[Abstract]
[DOI] [Full Text]

A tumour suppressor network relying on the polyamine-hypusine axis
Scuoppo C,
Miething C,
Lindqvist L,
Reyes J,
Ruse C,
Appelmann I,
Yoon S,
Krasnitz A,
Teruya-Feldstein J,
Pappin D,
Pelletier J,
Lowe SW

Nature
  487 (7406): 244-8; Jul 12 2012   NLM
[Abstract]
[DOI] [Full Text]

Proffered Paper: Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Hannon GJ,
Lowe SW,
Zuber J,
Elledge S

European Journal of Cancer
  48 (0): S14-S14; Jul 2012  
[Full Text]

Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma
Kitzing T,
Xue W,
Roessler S,
Krasnitz A,
Schultz N,
Wang XW,
Wigler M,
Lowe SW

European Journal of Cancer
  48 (0): S139-S139; Jul 2012  
[Full Text]

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
Chicas A,
Kapoor A,
Wang XW,
Aksoy O,
Evertts AG,
Zhang MQ,
Garcia BA,
Bernstein E,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  109 (23): 8971-8976; Jun 5 2012  
[Abstract]
[DOI] [Full Text]

Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor beta chain and KIT V654A
Spector MS,
Iossifov I,
Kritharis A,
He C,
Kolitz JE,
Lowe SW,
Allen SL

Leukemia
  26 (6): 1422-1425; Jun 2012  
[DOI] [Full Text]

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
Bergerson RJ,
Collier LS,
Sarver AL,
Been RA,
Lugthart S,
Diers MD,
Zuber J,
Rappaport AR,
Nixon MJ,
Silverstein KA,
Fan DH,
Lamblin AF,
Wolff L,
Kersey JH,
Delwel R,
Lowe SW,
OSullivan MG,
Kogan SC,
Adams DJ,
Largaespada DA

Blood
  119 (19): 4512-4523; May 10 2012  
[Abstract]
[DOI] [Full Text]

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
Xue W,
Kitzing T,
Roessler S,
Zuber J,
Krasnitz A,
Schultz N,
Revill K,
Weissmueller S,
Rappaport AR,
Simon J,
Zhang J,
Luo WJ,
Hicks J,
Zender L,
Wang XW,
Powers S,
Wigler M,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  109 (21): 8212-8217; May 2012  
[Abstract]
[DOI] [Full Text]

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis
Lin CJ,
Nasr Z,
Premsrirut P,
Porco Jr J,
Hippo Y,
Lowe S,
Pelletier J

Cell Reports
  1 (4): 325-333; Apr 19 2012  
[Abstract]
[DOI] [Full Text]

A pipeline for the generation of shRNA transgenic mice
Dow LE,
Premsrirut PK,
Zuber J,
Fellmann C,
McJunkin K,
Miething C,
Park Y,
Dickins RA,
Hannon GJ,
Lowe SW

Nat Protoc
  7 (2): 374-93; Feb 2 2012   NLM
[Abstract]
[DOI] [Full Text]

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy
Tan X,
Lu ZJ,
Gao G,
Xu QK,
Hu L,
Fellmann C,
Li MZ,
Qu HJ,
Lowe SW,
Hannon GJ,
Elledge SJ

Proceedings of the National Academy of Sciences of the United States of America
  109 (3): 869-874; Jan 2012  
[Abstract]
[DOI] [Full Text]

Anti-apoptotic mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Glaser SP,
Lee EF,
Trounson E,
Bouillet P,
Wei A,
Fairlie WD,
Izon DJ,
Zuber J,
Rappaport AR,
Herold MJ,
Alexander WS,
Lowe SW,
Robb L,
Strasser A

Genes and Development
  26 (2): 120-125; Jan 2012  
[Abstract]
[DOI] [Full Text]

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Freed-Pastor WA,
Mizuno H,
Zhao X,
Langerød A,
Moon SH,
Rodriguez-Barrueco R,
Barsotti A,
Chicas A,
Li W,
Polotskaia A,
Bissell MJ,
Osborne TF,
Tian B,
Lowe SW,
Silva JM,
Børresen-Dale AL,
Levine AJ,
Bargonetti J,
Prives C

Cell
  148 (1): 244-258; Jan 2012  
[Abstract]
[DOI] [Full Text]

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML
Herrmann H,
Blatt K,
Shi JW,
Rappaport AR,
Gleixner KV,
Cerny-Reiterer S,
Peter B,
Wang E,
Sperr WR,
Bradner JE,
Lowe SW,
Vakoc CR,
Zuber J,
Valent P

Blood
  118 (21): 1487-1487; Nov 2011  
[Full Text]

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias
Hein N,
Bywater MJ,
Stanley K,
Verbrugge I,
Cullinane C,
Baker A,
Zuber H,
Rappaport A,
Drygin D,
Huser N,
Bliesath J,
Ryckman DM,
Rice WG,
Lowe SW,
Johnstone RW,
Pearson RB,
McArthur GA,
Hannan RD

Blood
  118 (21): 673-673; Nov 2011  
[Full Text]

Control of the senescence-associated secretory phenotype by NF-{kappa}B promotes senescence and enhances chemosensitivity
Chien Y,
Scuoppo C,
Wang X,
Fang X,
Balgley B,
Bolden JE,
Premsrirut P,
Luo W,
Chicas A,
Lee CS,
Kogan SC,
Lowe SW

Genes Dev
  25 (20): 2125-2136; Oct 15 2011   NLM
[Abstract]
[DOI]

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber J,
Shi J,
Wang E,
Rappaport AR,
Herrmann H,
Sison EA,
Magoon D,
Qi J,
Blatt K,
Wunderlich M,
Taylor MJ,
Johns C,
Chicas A,
Mulloy JC,
Kogan SC,
Brown P,
Valent P,
Bradner JE,
Lowe SW,
Vakoc CR

Nature
  478 (7370): 524-528; Aug 3 2011   NLM
[Abstract]
[DOI]

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
Zuber J,
Rappaport AR,
Luo W,
Wang E,
Chen C,
Vaseva AV,
Shi J,
Weissmueller S,
Fellman C,
Taylor MJ,
Weissenboeck M,
Graeber TG,
Kogan SC,
Vakoc CR,
Lowe SW

Genes Dev
  25 (15): 1628-1640; Aug 1 2011  
[Abstract]
[DOI]

Reversible suppression of an essential gene in adult mice using transgenic RNA interference
McJunkin K,
Mazurek A,
Premsrirut PK,
Zuber J,
Dow LE,
Simon J,
Stillman B,
Lowe SW

Proc Natl Acad Sci U S A
  108 (17): 7113-7118; Apr 26 2011   NLM PMC3084121
[Abstract]
[DOI]

The Flt3 Internal Tandem Duplication Alters Chemotherapy Response In Vitro and In Vivo in a p53-Dependent Manner
Pardee TS,
Zuber J,
Lowe SW

Experimental Hematology
  39 (4): 473-485; Apr 2011   PMC3062750
[Abstract]
[DOI] [Full Text] [PDF]

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
Premsrirut PK,
Dow LE,
Kim SY,
Camiolo M,
Malone CD,
Miething C,
Scuoppo C,
Zuber J,
Dickins RA,
Kogan S,
Shroyer K,
Sordella R,
Hannon GJ,
Lowe SW

Cell
  145 (1): 145-158; Mar 31 2011   Elsevier
[Abstract]
[DOI]

Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
Fellmann C,
Zuber J,
McJunkin K,
Chang K,
Malone CD,
Dickins R,
Xu Q,
Hengartner M,
Elledge SJ,
Hannon GJ,
Lowe SW

Molecular Cell
  41 (6): 733-746; Mar 18 2011   Array
[Abstract]
[DOI]

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
Sawey ET,
Chanrion M,
Cai C,
Wu G,
Zhang J,
Zender L,
Zhao A,
Busuttil RW,
Yee H,
Stein LD,
French DM,
Finn RS,
Lowe SW,
Powers S

Cancer Cell
  19 (3): 347-358; Mar 8 2011   Elsevier PMC3061399
[Abstract]
[DOI]

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Xu MZ,
Chan SW,
Liu AM,
Wong KF,
Fan ST,
Chen J,
Poon RT,
Zender L,
Lowe SW,
Hong W,
Luk JM

Oncogene
  30 (10): 1229-1240; Mar 2011   ISI
[Abstract]
[DOI]

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Zuber J,
McJunkin K,
Fellmann C,
Dow L,
Taylor MJ,
Hannon GJ,
Lowe SW

Nature Biotechnology
  29 (1): 79-85; Jan 2011  
[Abstract]
[DOI] [Full Text] [PDF]

Distinct Expression Profiles of p63 Variants during Urothelial Development and Bladder Cancer Progression
Karni-Schmidt O,
Castillo-Martin M,
HuaiShen T,
Gladoun N,
Domingo-Domenech J,
Sanchez-Carbayo M,
Li Y,
Lowe SW,
Prives C,
Cordon-Cardo C

The American Journal of Pathology
  178 (3): 1350-1360; 2011   Elsevier PMC3069841
[Abstract]
[DOI]

Report from the fifth national cancer institute mouse models of human cancers consortium nervous system tumors workshop
Gutmann DH,
Stiles CD,
Lowe SW,
Bollag GE,
Furnari FB,
Charest A

Neuro-Oncology
  13 (7): 692-699; 2011   PMC3129277
[Abstract]
[DOI] [Full Text]

Mutation discovery in mice by whole exome sequencing
Fairfield H,
Gilbert GJ,
Barter M,
Corrigan RR,
Curtain M,
Ding YM,
DAscenzo M,
Gerhardt DJ,
He C,
Huang WH,
Richmond T,
Rowe L,
Probst FJ,
Bergstrom DE,
Murray SA,
Bult C,
Richardson J,
Kile BT,
Gut I,
Hager J,
Sigurdsson S,
Mauceli E,
Di Palma F,
Lindblad-Toh K,
Cunningham ML,
Cox TC,
Justice MJ,
Spector MS,
Lowe SW,
Albert T,
Donahue LR,
Jeddeloh J,
Shendure J,
Reinholdt LG

Genome Biology
  12 (9): 2011  
[Abstract]
[DOI] [Full Text]

Transgenic, inducible RNAi in megakaryocytes and platelets in mice
Takiguchi M,
James C,
Josefsson EC,
Carmichael CL,
Premsrirut PK,
Lowe SW,
Hamilton JR,
Huang DC,
Kile BT,
Dickins RA

J Thromb Haemost
  8 (12): 2751-6; Dec 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Mechanisms of action of histone deacetylase inhibitors (HDACi)
Newbold A,
Bots M,
Cluse L,
Lindemann R,
Lowe SW,
Richon V,
Secrist P,
Miller T,
Hardwick J,
Johnstone R

Ejc Supplements
  8 (7): 46-46; Nov 2010  
[DOI] [Full Text]

An RNA1 Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL AF9 Leukemia From Normal Hematopoietic Cells
Vakoc CR,
Zuber J,
Lowe S,
Wang E,
Rappaport AR,
Shi JW

Blood
  116 (21): 35-35; Nov 2010   ISI


Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis
Ko FC,
Chan LK,
Tung EK,
Lowe SW,
Ng IO,
Yam JW

Gastroenterology
  139 (4): Oct 2010  
[Abstract]
[DOI] [Full Text]

p16INK4a-mediated suppression of telomerase in normal and malignant human breast cells
Bazarov AV,
van Sluis M,
Hines WC,
Bassett E,
Beliveau A,
Campeau E,
Mukhopadhyay R,
Lee WJ,
Melodyev S,
Zaslavsky Y,
Lee L,
Rodier F,
Chicas A,
Lowe SW,
Benhattar J,
Ren B,
Campisi J,
Yaswen P

Aging Cell
  9 (5): 736-746; Oct 2010   PMC2941554
[Abstract]
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Nature Biotechnology
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Nature Reviews Cancer
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Genes Dev
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Nature
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Cancer Cell
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Proceedings of the National Academy of Sciences of the United States of America
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Nat Cell Biol
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Blood
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Hepatology
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Cancer Cell
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Cancer
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Mol Carcinog
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Blood
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Journal of Clinical Oncology
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PLoS ONE
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Genes Dev
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Cancer Res
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Journal of Investigative Medicine
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A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
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Nature Biotechnology
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International Journal of Radiation Oncology Biology Physics
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Nature
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Cell
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Nat Cell Biol
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Proc Natl Acad Sci U S A
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Cell
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Genes Dev
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Proc Natl Acad Sci U S A
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Ejc Supplements
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Proc Natl Acad Sci U S A
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J Clin Invest
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Proc Natl Acad Sci U S A
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Cell
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Onkologie
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Curr Opin Oncol
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Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology
Krizhanovsky V,
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Cold Spring Harb Symp Quant Biol
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Genes Dev
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Ellis L,
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Molecular Cancer Therapeutics
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microRNAs join the p53 network - another piece in the tumour-suppression puzzle
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Nat Rev Cancer
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p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing
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Oncogene
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Nat Genet
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Nature
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ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
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