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146 Article(s) on File
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Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models
Hua Y,
Liu YH,
Sahashi K,
Rigo F,
Bennett CF,
Krainer AR

Genes Dev
  (0): Jan 12 2015   Nlm
[Abstract]
[DOI] [Full Text]

The human splicing code reveals new insights into the genetic determinants of disease
Xiong HY,
Alipanahi B,
Lee LJ,
Bretschneider H,
Merico D,
Yuen RK,
Hua Y,
Gueroussov S,
Najafabadi HS,
Hughes TR,
Morris Q,
Barash Y,
Krainer AR,
Jojic N,
Scherer SW,
Blencowe BJ,
Frey BJ

Science
  (0): Dec 18 2014   Nlm
[Abstract]
[DOI] [Full Text]

HIV-1 transcription is regulated by splicing factor SRSF1
Paz S,
Krainer AR,
Caputi M

Nucleic Acids Research
  (0): Nov 21 2014   Nlm
[Abstract]
[DOI] [Full Text]

Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer
Das S,
Krainer AR

Molecular Cancer Research
  12 (9): 1195-1204; Sep 2014   NLM
[Abstract]
[DOI] [Full Text]

p53Psi is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state
Senturk S,
Yao Z,
Camiolo M,
Stiles B,
Rathod T,
Walsh AM,
Nemajerova A,
Lazzara MJ,
Altorki NK,
Krainer A,
Moll UM,
Lowe SW,
Cartegni L,
Sordella R

Proceedings of the National Academy of Sciences of the United States of America
  111 (32): E3287-E3296; Aug 12 2014   Nlm
[Abstract]
[DOI] [Full Text]

Pharmacology of a central nervous system delivered 2′-O-methoxyethyl- modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates
Rigo F,
Chun SJ,
Norris DA,
Hung G,
Lee S,
Matson J,
Fey RA,
Gaus H,
Hua Y,
Grundy JS,
Krainer AR,
Henry SP,
Bennett CF

Journal of Pharmacology and Experimental Therapeutics
  350 (1): 46-55; Jul 2014 2014   NLM
[Abstract]
[DOI] [Full Text]

Splicing factor SRSF6 promotes hyperplasia of sensitized skin
Jensen MA,
Wilkinson JE,
Krainer AR

Nature Structural and Molecular Biology
  21 (2): 189-97; Feb 2014 2014   NLM
[Abstract]
[DOI] [Full Text]

Pathological impact of SMN2 mis-splicing in adult SMA mice
Sahashi K,
Ling KK,
Hua Y,
Wilkinson JE,
Nomakuchi T,
Rigo F,
Hung G,
Xu D,
Jiang YP,
Lin RZ,
Ko CP,
Bennett CF,
Krainer AR

EMBO Mol Med
  5 (10): 1586-601; Oct 2013   NLM
[Abstract]
[DOI] [Full Text]

Pathological impact of SMN2 mis-splicing in adult SMA mice
Sahashi K,
Ling KK,
Hua Y,
Wilkinson JE,
Nomakuchi T,
Rigo F,
Hung G,
Xu D,
Jiang YP,
Lin RZ,
Ko CP,
Bennett CF,
Krainer AR

EMBO Mol Med
  5 (10): 1586-1601; Sep 9 2013   NLM
[Abstract]
[DOI] [Full Text]

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition
Cléry A,
Sinha R,
Anczuków O,
Corrionero A,
Moursy A,
Daubner GM,
Valcárcel J,
Krainer AR,
Allain FH

Proceedings of the National Academy of Sciences of the United States of America
  110 (30): E2802-E2811; Jul 23 2013   NLM
[Abstract]
[DOI] [Full Text]

A new path to oncogene-induced senescence: At the cross-roads of splicing and translation
Das S,
Fregoso OI,
Krainer AR

Cell Cycle
  12 (10): 1477-1479; May 15 2013   Nlm
[DOI] [Full Text]

Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence
Fregoso OI,
Das S,
Akerman M,
Krainer AR

Molecular Cell
  50 (1): 56-66; Apr 11 2013   TR
[Abstract]
[DOI] [Full Text]

OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds
Wu J,
Anczukow O,
Krainer AR,
Zhang MQ,
Zhang C

Nucleic Acids Res
  16 (6): 5149-5163; Apr 9 2013   NLM
[Abstract]
[DOI] [Full Text]

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1
Ben-Hur V,
Denichenko P,
Siegfried Z,
Maimon A,
Krainer A,
Davidson B,
Karni R

Cell Reports
  3 (1): 103-115; Jan 2013   NLM
[DOI] [Full Text]

Pick one, but be quick: 5′ splice sites and the problems of too many choices
Roca X,
Krainer AR,
Eperon IC

Genes and Development
  27 (2): 129-144; Jan 2013  
[Abstract]
[DOI] [Full Text]

Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies
Krainer A

Blood
  120 (21): Nov 2012  
[Abstract]
[Full Text]

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
Wang Z,
Jeon HY,
Rigo F,
Bennett CF,
Krainer AR

Open Biol
  2 (10): 120133; Oct 2012   NLM
[Abstract]
[DOI] [Full Text]

Antisense-based therapy for the treatment of spinal muscular atrophy
Rigo F,
Hua YM,
Krainer AR,
Bennett CF

Journal of Cell Biology
  199 (1): 21-25; Oct 1 2012  
[Abstract]
[DOI] [Full Text]

TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals
Sahashi K,
Hua Y,
Ling KK,
Hung G,
Rigo F,
Horev G,
Katsuno M,
Sobue G,
Ko CP,
Bennett CF,
Krainer AR

Genes Dev
  26 (16): 1874-84; Aug 15 2012   NLM
[Abstract]
[DOI] [Full Text]

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing
Rigo F,
Hua YM,
Chun SJ,
Prakash TP,
Krainer AR,
Bennett CF

Nature Chemical Biology
  8 (6): 555-561; Jun 2012  
[Abstract]
[DOI] [Full Text]

A generalizable pre-clinical research approach for orphan disease therapy
Beaulieu CL,
Samuels ME,
Ekins S,
McMaster CR,
Edwards AM,
Krainer AR,
Hicks GG,
Frey BJ,
Boycott KM,
Mackenzie AE

Orphanet J Rare Dis
  7 (0): 1750-1172; Jun 2012   NLM
[Abstract]
[DOI] [Full Text]

Widespread recognition of 5 splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides
Roca X,
Akerman M,
Gaus H,
Berdeja A,
Bennett CF,
Krainer AR

Genes Development
  26 (10): 1098-109; May 15 2012   Nlm
[Abstract]
[DOI] [Full Text]

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
Wang ZX,
Chatterjee D,
Jeon HY,
Akerman M,
Vander Heiden MG,
Cantley LC,
Krainer AR

Journal of Molecular Cell Biology
  4 (2): 79-87; Apr 2012  
[Abstract]
[DOI] [Full Text]

Antisense-mediated exon inclusion
Hua Y,
Krainer AR

Methods Mol Biol
  867 (0): 307-23; Mar 2012   NLM
[Abstract]
[DOI] [Full Text]

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
Das S,
Anczuków O,
Akerman M,
Krainer A

Cell Reports
  1 (2): 110-117; Feb 23 2012  
[Abstract]
[DOI] [Full Text]

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2
Sun SY,
Zhang Z,
Fregoso O,
Krainer AR

RNA
  18 (2): 274-283; Feb 2012  
[Abstract]
[DOI] [Full Text]

RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
Kole R,
Krainer AR,
Altman S

Nature Reviews Drug Discovery
  11 (2): 125-140; Feb 2012  
[Abstract]
[DOI] [Full Text]

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Anczukow O,
Rosenberg AZ,
Akerman M,
Das S,
Zhan L,
Karni R,
Muthuswamy SK,
Krainer AR

Nat Struct Mol Biol
  19 (2): 220-228; Jan 15 2012   NLM
[Abstract]
[DOI] [Full Text]

SpliceTrap: a method to quantify alternative splicing under single cellular conditions
Wu J,
Akerman M,
Sun S,
McCombie WR,
Krainer AR,
Zhang MQ

Bioinformatics
  27 (21): 3010-3016 ; Nov 2011   PMC3198574
[Abstract]
[DOI]

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model
Hua Y,
Sahashi K,
Rigo F,
Hung G,
Horev G,
Bennett CF,
Krainer AR

Nature
  478 (7367): 123-6; Oct 6 2011   NLM
[Abstract]
[DOI] [Full Text]

A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia
Kubota T,
Roca X,
Kimura T,
Kokunai Y,
Nishino I,
Sakoda S,
Krainer AR,
Takahashi MP

Human Mutation
  32 (7): 773-782; Jul 2011  
[Abstract]
[DOI] [Full Text]

Oligonucleotide therapeutics for correcting defective rna splicing
Krainer AR

Febs Journal
  278 (0): 11-11; Jun 2011   PMC3140428
[Full Text]

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly
Cho SY,
Hoang A,
Sinha R,
Zhong XY,
Fu XD,
Krainer AR,
Ghosh G

Proceedings of the National Academy of Sciences of the United States of America
  108 (20): 8233-8238; May 17 2011   PMC3100968
[Abstract]
[DOI]

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy
Passini MA,
Bu J,
Richards AM,
Kinnecom C,
Sardi SP,
Stanek LM,
Hua ,
Rigo F,
Matson J,
Hung G,
Kaye EM,
Shihabuddin LS,
Krainer AR,
Bennett CF,
Cheng SH

Science Translational Medicine
  3 (72): Mar 2 2011   Elsevier PMC3140425
[Abstract]
[DOI]

Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway
Thorsen K,
Mansilla F,
Schepeler T,
OSTER B,
Rasmussen MH,
DYRSKJOT L,
Karni R,
Akerman M,
Krainer AR,
Laurberg S,
Andersen CL,
ORNTOFT TF

Molecular and Cellular Proteomics
  10 (1): Jan 1 2011   PMC3013455
[Abstract]
[DOI]

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model
Hua Y,
Sahashi K,
Hung G,
Rigo F,
Passini MA,
Bennett CF,
Krainer AR

Genes Dev
  24 (15): 1634-44; Aug 1 2010   PMCID: PMC2912561
[Abstract]
[DOI] [Full Text] [PDF]

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing
Wu H,
Sun S,
Tu K,
Gao Y,
Xie B,
Krainer AR,
Zhu J

Molecular Cell
  38 (1): 67-77; Apr 9 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF
Sinha R,
Allemand E,
Zhang Z,
Karni R,
Myers MP,
Krainer AR

Mol Cell Biol
  (0): Mar 22 2010   PMCID: PMC2876523
[Abstract]
[DOI] [Full Text] [PDF]

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
Sun S,
Zhang Z,
Sinha R,
Karni R,
Krainer AR

Nat Struct Mol Biol
  (0): Feb 7 2010   PMCID: PMC2921916
[Abstract]
[DOI] [Full Text] [PDF]

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
Clower CV,
Chatterjee D,
Wang ZX,
Cantley LC,
Heiden MG,
Krainer AR

Proceedings of the National Academy of Sciences of the United States of America
  107 (5): 1894-1899; Feb 2 2010   PMCID: PMC2838216
[Abstract]
[DOI] [Full Text] [PDF]

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)
Manley JL,
Krainer AR

Genes and Development
  24 (11): 1073-1074; 2010   PMCID: PMC2878644
[DOI] [Full Text] [PDF]

Cooperative-binding and splicing-repressive properties of hnRNP A1
Okunola HL,
Krainer AR

Mol Cell Biol
  29 (20): 5620-5631; Oct 2009   PMCID: PMC2756886
[Abstract]
[DOI] [Full Text] [PDF]

A Positive Modifier of Spinal Muscular Atrophy in the SMN2 Gene
Prior TW,
Krainer AR,
Hua Y,
Swoboda KJ,
Snyder PC,
Bridgeman SJ,
Burghes AH,
Kissel JT

The American Journal of Human Genetics
  85 (3): 408-413; Sep 11 2009   PMCID: PMC2771537
[Abstract]
[DOI] [Full Text] [PDF]

Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP
De Araújo MM,
Bonnal S,
Hastings ML,
Krainer AR,
Valcárcel J

RNA
  15 (4): 515-523; Apr 2009   PMCID: PMC2661831
[Abstract]
[DOI] [Full Text] [PDF]

Splicing therapeutics in SMN2 and APOB
Khoo B,
Krainer AR

Current Opinion in Molecular Therapeutics
  11 (2): 108-115; Apr 2009   PMC3140428
[Abstract]
[Full Text]

A splicing component adapted to gene silencing
Roca X,
Krainer AR

Nat Biotechnol
  27 (3): 250-1; Mar 2009   NLM
[DOI]

Recognition of atypical 5 splice sites by shifted base-pairing to U1 snRNA
Roca X,
Krainer AR

Nat Struct Mol Biol
  16 (2): 176-182; Feb 2009   PMCID: PMC2719486
[Abstract]
[DOI] [Full Text] [PDF]

The splicing-factor oncoprotein SF2/ASF activates mTORC1
Karni R,
Hippo Y,
Lowe SW,
Krainer AR

Proc Natl Acad Sci U S A
  105 (40): 15323-7; Oct 7 2008   PMCID: PMC2563124
[Abstract]
[DOI] [Full Text] [PDF]

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
Zhang C,
Zhang Z,
Castle J,
Sun S,
Johnson J,
Krainer AR,
Zhang MQ

Genes Dev
  22 (18): 2550-63; Sep 15 2008   PMCID: PMC2546699
[Abstract]
[DOI] [Full Text] [PDF]

Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis
Thorsen K,
Sorensen KD,
Brems-Eskildsen AS,
Modin C,
Gaustadnes M,
Hein AM,
Kruhoffer M,
Laurberg S,
Borre M,
Wang K,
Brunak S,
Krainer AR,
Torring N,
Dyrskjot L,
Andersen CL,
Orntoft TF

Molecular Cellular Proteomics
  7 (7): 1214-1224; Jul 2008  
[Abstract]
[DOI] [Full Text]

Where in the cell is the minor spliceosome?
Steitz JA,
Dreyfuss G,
Krainer AR,
Lamond AI,
Matera AG,
Padgett RA

Proc Natl Acad Sci U S A
  105 (25): 8485-6; Jun 24 2008   PMCID: PMC2438384
[DOI] [Full Text] [PDF]

RNA landscape of evolution for optimal exon and intron discrimination
Zhang C,
Li WH,
Krainer AR,
Zhang MQ

Proc Natl Acad Sci U S A
  105 (15): 5797-5802 ; Apr 15 2008   PMCID: PMC2311341
[Abstract]
[DOI] [Full Text] [PDF]

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice
Hua Y,
Vickers TA,
Okunola HL,
Bennett CF,
Krainer AR

Am J Hum Genet
  82 (4): 834-48; Apr 2008   PMCID: PMC2427210
[Abstract]
[DOI] [Full Text] [PDF]

Kaposi sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes the expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing
Majerciak V,
Yamanegi K,
Allemand E,
Kruhlak M,
Krainer AR,
Zheng ZM

J Virol
  82 (6): 2792-2801; Mar 2008   PMCID: PMC2258979
[Abstract]
[DOI] [Full Text] [PDF]

Features of 5-splice-site efficiency derived from disease-causing mutations and comparative genomics
Roca X,
Olson AJ,
Rao AR,
Enerly E,
Kristensen VN,
Borresen-Dale AL,
Andresen BS,
Krainer AR,
Sachidanandam R

Genome Res
  18 (1): 77-87; Jan 2008   PMCID: PMC2134769
[Abstract]
[DOI] [Full Text] [PDF]

Identification of synaptic targets of Drosophila Pumilio
Chen G,
Li W,
Zhang Q,
Regulski MR,
Sinha N,
Barditch J,
Tully T,
Krainer AR,
Zhang MQ,
Dubnau JT

PLoS computational biology
  4 (2): e1000026 ; 2008  
[Full Text]

Evolutionary impact of limited splicing fidelity in mammalian genes
Zhang C,
Krainer AR,
Zhang MQ

Trends Genet
  23 (10): 484-488; Oct 2007  
[Abstract]
[DOI] [Full Text] [PDF]

The pathology of pre-mRNA splicing: a meeting in the Italian Alps - Workshop on pre-mRNA processing and disease
Caceres JF,
Krainer AR,
Kornblihtt AR

Embo Reports
  8 (8): 730-734; Aug 2007  
[DOI] [Full Text] [PDF]

Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components
Zhang Z,
Krainer AR

Proc Natl Acad Sci U S A
  104 (28): 11574-9; Jul 10 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1
Allemand E,
Hastings ML,
Murray MV,
Myers MP,
Krainer AR

Nat Struct Mol Biol
  14 (7): 630-638; Jul 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65
Hastings ML,
Allemand E,
Duelli DM,
Myers MP,
Krainer AR

PLoS ONE
  2 (6): e538; Jun 20 2007   PMCID: PMC1888729
[Abstract]
[DOI] [Full Text] [PDF]

Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5 splice-site disruption
Wimmer K,
Roca X,
Beiglbock H,
Callens T,
Etzler J,
Rao AR,
Krainer AR,
Fonatsch C,
Messiaen L

Human Mutation
  28 (6): 599-612; Jun 2007  
[Abstract]
[Full Text]

SR proteins function in coupling RNAP II transcription to pre-mRNA splicing
Das R,
Yu J,
Zhang Z,
Gygi MP,
Krainer AR,
Gygi SP,
Reed R

Mol Cell
  26 (6): 867-881; Jun 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Enhancement of SMN2 Exon 7 inclusion by antisense oligonucleotides targeting the exon
Hua YM,
Vickers TA,
Baker BF,
Bennett CF,
Krainer AR

PLoS Biology
  5 (4): e73; Apr 2007   PMCID: PMC1820610
[Abstract]
[DOI] [Full Text] [PDF]

Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: A synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer
Nielsen KB,
Sorensen S,
Cartegni L,
Corydon TJ,
Doktor TK,
Schroeder LD,
Reinert LS,
Elpeleg O,
Krainer AR,
Gregersen N,
Kjems J,
Andresen BS

American Journal of Human Genetics
  80 (3): 416-432; Mar 2007  
[Abstract]
[PDF]

The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Karni R,
de Stanchina E,
Lowe SW,
Sinha R,
Mu D,
Krainer AR

Nat Struct Mol Biol
  14 (3): 185-93; Mar 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing
Shaw SD,
Chakrabarti S,
Ghosh G,
Krainer AR

PLoS ONE
  2 (9): e854; 2007   PMCID: PMC1952110
[Abstract]
[DOI] [Full Text] [PDF]

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
Khoo B,
Roca X,
Chew SL,
Krainer AR

Bmc Molecular Biology
  8 (0): Jan 2007  
[Abstract]
[DOI] [Full Text] [PDF]

hnRNP A1 associates with telomere ends and stimulates telomerase activity
Zhang Q,
Manche L,
Xu RM,
Krainer AR

RNA
  12 (6): 1116-28; Jun 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2
Cartegni L,
Hastings ML,
Calarco JA,
de Stanchina E,
Krainer AR

Am J Hum Genet
  78 (1): 63-77; Jan 2006  
[Abstract]
[DOI] [Full Text] [PDF]

The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha (repressor) in human myometrial cells is mediated by SRp40
Tyson-Capper AJ,
Bailey J,
Krainer AR,
Robson SC,
Europe-Finner GN

Journal of Biological Chemistry
  280 (41): 34521-34529; Oct 2005  
[Abstract]
[Full Text]

Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes
Wang J,
Smith PJ,
Krainer AR,
Zhang MQ

Nucleic Acids Res
  33 (16): 5053-62; 2005  
[Abstract]
[DOI]

Functional significance of deep intronic mutation in the ATM gene and evidence for an alternative Exon 28a
Coutinho G,
Xie JY,
Du LT,
Brusco A,
Krainer AR,
Gatti RA

Human Mutation
  25 (2): 118-124; 2005  
[Abstract]
[DOI] [Full Text]

Involvement of SR proteins in mRNA surveillance
Zhang Z,
Krainer AR

Mol Cell
  16 (4): 597-607; Nov 19 2004  
[Abstract]
[DOI] [Full Text]

Manipulation of alternative splicing by a newly developed inhibitor of Clks
Muraki M,
Ohkawara B,
Hosoya T,
Onogi H,
Koizumi J,
Koizumi T,
Sumi K,
Jun-ichiro Y,
Murray MV,
Kimura H,
Furuichi K,
Shibuya H,
Krainer AR,
Suzuki M,
Hagiwara M

Journal of Biological Chemistry
  279 (23): 24246-24254; Jun 2004  
[Abstract]
[DOI] [Full Text] [PDF]

Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1
Zatkova A,
Messiaen L,
Vandenbroucke I,
Wieser R,
Fonatsch C,
Krainer AR,
Wimmer K

Human Mutation
  24 (6): 491-501; 2004  
[Abstract]
[Full Text]

Manipulation of alternative splicing by a novel inhibitor of Clks
Muraki M,
Ohkawara B,
Hosoya T,
Onogi H,
Koizumi J,
Koizumi T,
Sumi K,
Yomoda J,
Murray MV,
Kimura H,
Furuichi K,
Shibuya H,
Krainer AR,
Suzuki M,
Hagiwara M

Journal of Pharmacological Sciences
  94 (0): 244P-244P; 2004  
[Full Text]

Human immunodeficiency virus type 1 hnRNP A/B-Dep endent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts
Domsic JK,
Wang YB,
Mayeda A,
Krainer AR,
Stoltzfus CM

Molecular and Cellular Biology
  23 (23): 8762-8772; Dec 2003  
[Abstract]
[Full Text]

Intrinsic differences between authentic and cryptic 5 splice sites
Roca X,
Sachidanandam R,
Krainer AR

Nucleic Acids Research
  31 (21): 6321-6333; Nov 2003  
[Abstract]
[Full Text]

ESEfinder: a web resource to identify exonic splicing enhancers
Cartegni L,
Wang JH,
Zhu ZW,
Zhang MQ,
Krainer AR

Nucleic Acids Research
  31 (13): 3568-3571; Jul 2003  
[Abstract]
[Full Text]

Correction of disease-associated exon skipping by synthetic exon-specific activators
Cartegni L,
Krainer AR

Nature Structural Biology
  10 (2): 120-125; Feb 2003  
[Abstract]
[Full Text]

Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch
Hou VC,
Lersch R,
Gee SL,
Ponthier JL,
Lo AJ,
Wu M,
Turck CW,
Koury M,
Krainer AR,
Mayeda A,
Conboy JG

Embo Journal
  21 (22): 6195-6204; Nov 2002  
[Full Text]

Nuclear export and retention signals in the RS domain of SR proteins
Cazalla D,
Zhu J,
Manche L,
Huber E,
Krainer AR,
Caceres JF

Molecular and Cellular Biology
  22 (19): 6871-6882; Oct 2002  
[Full Text]

Simple mutations in the coding region of three acyl-CoA dehydrogenase genes may lead to skipping of the constitutive exon due to disruption of potential splice enhancer sequences or mRNA secondary structures
Andresen BS,
Nielsen KB,
Madsen PP,
Corydon TJ,
Kjems J,
Krainer AR,
Elpeleg ON,
Schroeder LD,
Gregersen N

American Journal of Human Genetics
  71 (4): 196-196; Oct 2002  
[Full Text]

BRCA2 T2722R is a deleterious allele that causes exon skipping
Fackenthal JD,
Cartegni L,
Krainer AR,
Olopade OI

American Journal of Human Genetics
  71 (3): 625-631; Sep 2002  
[Full Text]

Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1
Vitali J,
Ding JZ,
Jiang JZ,
Zhang Y,
Krainer AR,
Xu RM

Nucleic Acids Research
  30 (7): 1531-1538; Apr 2002  
[Full Text]

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1
Cartegni L,
Krainer AR

Nature Genetics
  30 (4): 377-384; Apr 2002  
[Full Text]

Listening to silence and understanding nonsense: Exonic mutations that affect splicing
Cartegni L,
Chew SL,
Krainer AR

Nature Reviews Genetics
  3 (4): 285-298; Apr 2002  
[Full Text]

Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing
Dance GS,
Sowden MP,
Cartegni L,
Cooper E,
Krainer AR,
Smith HC

Journal of Biological Chemistry
  277 (15): 12703-12709; Apr 2002  
[Full Text]

An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor
Smith PJ,
Spurrell EL,
Coakley J,
Hinds CJ,
Ross RJ,
Krainer AR,
Chew SL

Endocrinology
  143 (1): 146-154; Jan 2002  
[Full Text]

Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins
Zhu J,
Mayeda A,
Krainer AR

Molecular Cell
  8 (6): 1351-1361; Dec 2001  
[Abstract]
[DOI] [Full Text]

Characterization of a second hnRNP A/B-dependent exonic splicing silencer in protein 4.1R exon 16
Hou VC,
Gee SL,
Wu M,
Turck CW,
Koury M,
Krainer AR,
Mayeda A,
Conboy JG

Blood
  98 (11): 436A-436A; Nov 2001  
[Full Text]

RNA splicing at human immunodeficiency virus type 1 3 splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element
Bilodeau PS,
Domsic JK,
Mayeda A,
Krainer AR,
Stoltzfus CM

Journal of Virology
  75 (18): 8487-8497; Sep 2001  
[Abstract]
[Full Text]

Pre-mRNA splicing in the new millennium
Hastings ML,
Krainer AR

Current Opinion in Cell Biology
  13 (3): 302-309; Jun 2001  
[Abstract]
[Full Text]

Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway
Hastings ML,
Krainer AR

Rna-a Publication of the Rna Society
  7 (3): 471-482; Mar 2001  
[Abstract]
[Full Text]

The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins
Nilsson CE,
Petersen-Mahrt S,
Durot C,
Shtrichman R,
Krainer AR,
Kleinberger T,
Akusjarvi G

Embo Journal
  20 (4): 864-871; Feb 2001  
[Abstract]
[Full Text]

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
Liu HX,
Cartegni L,
Zhang MQ,
Krainer AR

Nature Genetics
  27 (1): 55-58; Jan 2001  
[Abstract]
[DOI] [Full Text]

Pre-mRNA splicing in the absence of an SR protein RS domain
Zhu J,
Krainer AR

Genes Development
  14 (24): 3166-3178; Dec 2000  
[Abstract]
[Full Text]

Selection of alternative 5 splice sites: Role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1
Eperon IC,
Makarova OV,
Mayeda A,
Munroe SH,
Caceres JF,
Hayward DG,
Krainer AR

Molecular and Cellular Biology
  20 (22): 8303-8318; Nov 2000  
[Abstract]
[Full Text]

Human p32: A coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication
Van Scoy S,
Watakabe I,
Krainer AR,
Hearing J

Virology
  275 (1): 145-157; Sep 2000  
[Abstract]
[Full Text]

Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer
Dirksen WP,
Li XL,
Mayeda A,
Krainer AR,
Rottman FM

Journal of Biological Chemistry
  275 (37): 29170-29177; Sep 2000  
[Abstract]
[Full Text]

NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry
Boudrez A,
Beullens M,
Groenen P,
Van Eynde A,
Vulsteke V,
Jagiello I,
Murray M,
Krainer AR,
Stalmans W,
Bollen M

Journal of Biological Chemistry
  275 (33): 25411-25417; Aug 2000  
[Abstract]
[Full Text]

Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1(B) in the myometrium of the pregnant human uterus: A molecular mechanism for regulating regional protein isoform expression in vivo
Pollard AJ,
Sparey C,
Robson SC,
Krainer AR,
Europe-Finner GN

Journal of Clinical Endocrinology and Metabolism
  85 (5): 1928-1936; May 2000  
[Abstract]
[Full Text]

The MKK3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
van Oordt WV,
Diaz-Meco MT,
Lozano J,
Krainer AR,
Moscat J,
Caceres JE

Journal of Cell Biology
  149 (2): 307-316; Apr 2000   PMCID: PMC2175157
[Abstract]
[Full Text] [PDF]

Exonic splicing enhancer motif recognized by human SC35 under splicing conditions
Liu HX,
Chew SL,
Cartegni L,
Zhang MQ,
Krainer AR

Molecular and Cellular Biology
  20 (3): 1063-1071; Feb 2000  
[Abstract]
[Full Text]

Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing
Chew SL,
Liu HX,
Mayeda A,
Krainer AR

Proc Natl Acad Sci U S A
  96 (19): 10655-60; Sep 14 1999  
[Abstract]
[Full Text]

AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes
Wu Q,
Krainer AR

Mol Cell Biol
  19 (5): 3225-36; May 1999  
[Full Text]

Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein
Jiang J,
Zhang Y,
Krainer AR,
Xu RM

Proc Natl Acad Sci U S A
  96 (7): 3572-7; Mar 30 1999  
[Abstract]
[Full Text]

Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements
Mayeda A,
Screaton GR,
Chandler SD,
Fu XD,
Krainer AR

Mol Cell Biol
  19 (3): 1853-63; Mar 1999  
[Abstract]
[Full Text]

The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor
Murray MV,
Kobayashi R,
Krainer AR

Genes Dev
  13 (1): 87-97; Jan 1 1999  
[Abstract]
[Full Text]

Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP
Wu Q,
Krainer AR

Rna
  4 (12): 1664-73; Dec 1998  
[Abstract]
[Full Text]

Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1
Mayeda A,
Munroe SH,
Xu RM,
Krainer AR

Rna
  4 (9): 1111-23; Sep 1998  
[Abstract]
[Full Text]

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins
Liu HX,
Zhang M,
Krainer AR

Genes Dev
  12 (13): 1998-2012; Jul 1 1998  
[Abstract]
[Full Text]

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors
Hanamura A,
Caceres JF,
Mayeda A,
Franza BR,
Krainer AR

Rna
  4 (4): 430-44; Apr 1998  
[Abstract]
[Full Text]

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
Caceres JF,
Screaton GR,
Krainer AR

Genes Dev
  12 (1): 55-66; Jan 1 1998  
[Abstract]
[DOI] [Full Text] [PDF]

A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs
Horowitz DS,
Kobayashi R,
Krainer AR

Rna
  3 (12): 1374-87; Dec 1997  
[Abstract]
[Full Text]

Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs
Wu Q,
Krainer AR

Rna
  3 (6): 586-601; Jun 1997  
[Abstract]
[Full Text]

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs
Xu RM,
Jokhan L,
Cheng X,
Mayeda A,
Krainer AR

Structure
  5 (4): 559-70; Apr 15 1997  
[Abstract]
[Full Text]

A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor
Horowitz DS,
Krainer AR

Genes Dev
  11 (1): 139-51; Jan 1 1997  
[Abstract]
[Full Text]

U1-mediated exon definition interactions between AT-AC and GT-AG introns
Wu Q,
Krainer AR

Science
  274 (5289): 1005-8; Nov 8 1996  
[Abstract]
[Full Text]

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins
Mayeda A,
Munroe SH,
Caceres JF,
Krainer AR

Embo J
  13 (22): 5483-95; Nov 15 1994  
[Abstract]
[Full Text]

Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors
Caceres JF,
Stamm S,
Helfman DM,
Krainer AR

Science
  265 (5179): 1706-9; Sep 16 1994  
[Abstract]
[Full Text]

Mechanisms for selecting 5 splice sites in mammalian pre-mRNA splicing
Horowitz DS,
Krainer AR

Trends Genet
  10 (3): 100-6; Mar 1994  
[Abstract]
[DOI] [Full Text]

Role of Hnrnp A1 Structural Domains in Messenger-Rna Splicing and Rna-Rna Annealing
Monroe SH,
Mayeda A,
Krainer AR

Journal of Cellular Biochemistry
  (0): 116-116; Feb 1994  


The C-Protein Tetramer Binds 230 to 240 Nucleotides of Premessenger Rna and Nucleates the Assembly of 40s Heterogeneous Nuclear Ribonucleoprotein-Particles
Huang M,
Rech JE,
Northington SJ,
Flicker PF,
Mayeda A,
Krainer AR,
Lestourgeon WM

Molecular and Cellular Biology
  14 (1): 518-533; Jan 1994  
[Abstract]
[DOI] [Full Text]

Nonradioactive Detection of M(3)G Capped Rnas by Immunoblotting
Stamm S,
Mulligan GJ,
Krainer AR,
Helfman DM

Nucleic Acids Research
  22 (2): 252-253; Jan 1994  
[Full Text]

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors
Birney E,
Kumar S,
Krainer AR

Nucleic Acids Res
  21 (25): 5803-16; Dec 25 1993  
[Abstract]


General Splicing Factor Sf2 Asf Promotes Alternative Splicing by Binding to an Exonic Splicing Enhancer
Sun Q,
Mayeda A,
Hampson RK,
Krainer AR,
Rottman FM

Genes Development
  7 (12): 2598-2608; Dec 1993  
[Abstract]
[Full Text]

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains
Cáceres JF,
Krainer AR

Embo J
  12 (12): 4715-26; Dec 1993  
[Abstract]
[Full Text]

Pathways for Selection of 5 Splice Sites by U1 Snrnps and Sf2/Asf
Eperon IC,
Ireland DC,
Smith RA,
Mayeda A,
Krainer AR

Embo Journal
  12 (9): 3607-3617; Sep 1993  
[Abstract]
[Full Text]

Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6
Dong B,
Horowitz DS,
Kobayashi R,
Krainer AR

Nucleic Acids Res
  21 (17): 4085-92; Aug 25 1993  
[Abstract]


Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF
Mayeda A,
Helfman DM,
Krainer AR

Mol Cell Biol
  13 (5): 2993-3001; May 1993  
[Abstract]


General Splicing Factors Sf2 and Sc35 Have Equivalent Activities Invitro, and Both Affect Alternative 5 and 3 Splice Site Selection
Fu XD,
Mayeda A,
Maniatis T,
Krainer AR

Proceedings of the National Academy of Sciences of the United States of America
  89 (23): 11224-11228; Dec 1992  
[Abstract]
[Full Text]

A putative homolog of U2AF65 in S. cerevisiae
Birney E,
Kumar S,
Krainer AR

Nucleic Acids Res
  20 (17): 4663; Sep 11 1992  
[Full Text]

Independent Deposition of Heterogeneous Nuclear Ribonucleoproteins and Small Nuclear Ribonucleoprotein-Particles at Sites of Transcription
Amero SA,
Raychaudhuri G,
Cass CL,
Vanvenrooij WJ,
Habets WJ,
Krainer AR,
Beyer AL

Proceedings of the National Academy of Sciences of the United States of America
  89 (18): 8409-8413; Sep 1992  
[Abstract]
[Full Text]

2 Members of a Conserved Family of Nuclear Phosphoproteins Are Involved in Pre-Messenger-Rna Splicing
Mayeda A,
Zahler AM,
Krainer AR,
Roth MB

Proceedings of the National Academy of Sciences of the United States of America
  89 (4): 1301-1304; Feb 1992  
[Abstract]
[Full Text]

Regulation of Alternative Pre-Messenger-Rna Splicing by Hnrnp-A1 and Splicing Factor-Sf2
Mayeda A,
Krainer AR

Cell
  68 (2): 365-375; Jan 1992  
[Abstract]
[Full Text] [PDF]

Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators
Krainer AR,
Mayeda A,
Kozak D,
Binns G

Cell
  66 (2): 383-94; Jul 26 1991  
[Abstract]
[Full Text]

Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation
Mayeda A,
Krainer AR

Biotechniques
  10 (2): 182; Feb 1991  
[Full Text]

Long-Term Storage of Concentrated Tris Borate Edta Electrophoresis Buffers without Precipitation
Mayeda A,
Krainer AR

Biotechniques
  10 (2): 182; 1991  


Biochemistry of Mammalian Nuclear Pre-Messenger Rna Splicing and Splice Site Selection
Krainer AR,
Mayeda A,
Helfman D,
Conway GC,
Kozak D

Journal of Cellular Biochemistry - Supplement.(15 PART D)
  (0): 45; 1991  


The essential pre-mRNA splicing factor SF2 influences 5 splice site selection by activating proximal sites
Krainer AR,
Conway GC,
Kozak D

Cell
  62 (1): 35-42; Jul 13 1990  
[Abstract]
[Full Text]

The Essential Pre-Messenger-Rna Splicing Factor-Sf2 Influences 5 Splice Site Selection by Activating Proximal Sites
Krainer AR,
Conway GC,
Kozak D

Cell
  62 (1): 35-42; Jul 1990  
[Full Text]

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells
Krainer AR,
Conway GC,
Kozak D

Genes Dev
  4 (7): 1158-71; Jul 1990  
[Abstract]
[Full Text]

The U6 Small Nuclear-Rna from Trypanosoma-Brucei
Tschudi C,
Krainer AR,
Ullu E

Nucleic Acids Research
  16 (23): 11375-11375; Dec 1988  
[Full Text]

Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs
Krainer AR

Nucleic Acids Res
  16 (20): 9415-29; Oct 25 1988  
[Abstract]
[Full Text]


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