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60 Article(s) on File
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From guide to target: molecular insights into eukaryotic RNA-interference machinery
Ipsaro JJ,
Joshua-Tor L

Nat Struct Mol Biol
  22 (1): 20-28; Jan 7 2015   Nlm
[Abstract]
[DOI] [Full Text]

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway
Faehnle CR,
Walleshauser J,
Joshua-Tor L

Nature
  514 (7521): 252-6; Oct 9 2014   Nlm
[Abstract]
[DOI] [Full Text]

Dynamic look at DNA unwinding by a replicative helicase
Lee SJ,
Syed S,
Enemark EJ,
Schuck S,
Stenlund A,
Ha T,
Joshua-Tor L

Proceedings of the National Academy of Sciences of the United States of America
  111 (9): E827-E835; Mar 4 2014   NLM
[Abstract]
[DOI] [Full Text]

Slicer and the Argonautes
Faehnle CR,
Elkayam E,
Haase AD,
Hannon GJ,
Joshua-Tor L

Biophysical Journal
  106 (2): 455A-455A; Jan 28 2014   Thomson-Reuters
[Abstract]
[DOI] [Full Text]

CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing
Kuscu C,
Zaratiegui M,
Kim HS,
Wah DA,
Martienssen RA,
Schalch T,
Joshua-Tor L

Proc Natl Acad Sci U S A
  (0): Jan 21 2014   Nlm
[Abstract]
[DOI] [Full Text]

Eukaryotic Argonautes come into focus
Kuhn CD,
Joshua-Tor L

Trends Biochem Sci
  38 (5): 263-271; May 2013   NLM
[Abstract]
[DOI] [Full Text]

Upstream activation of PTEN
Naguib A,
Bencze G,
Faehnle CR,
Schalch T,
Lazar Z,
Ruse CI,
Joshua-Tor L,
Pappin DJ,
Trotman LC

Cancer Research
  73 (8): 5156; Apr 2013  
[Abstract]
[DOI] [Full Text]

Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression
Paul S,
Kuo A,
Schalch T,
Vogel H,
Joshua-Tor L,
McCombie WR,
Gozani O,
Hammell M,
Mills AA

Cell Rep
  3 (1): 92-102; Jan 10 2013   NLM
[Abstract]
[DOI] [Full Text]

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
Ipsaro JJ,
Haase AD,
Knott SR,
Joshua-Tor L,
Hannon GJ

Nature
  491 (7423): 279-83; Nov 8 2012   NLM
[Abstract]
[DOI] [Full Text]

A triple helix stabilizes the 3 ends of long noncoding RNAs that lack poly(A) tails
Wilusz JE,
Jnbaptiste CK,
Lu LY,
Kuhn CD,
Joshua-Tor L,
Sharp PA

Genes Dev
  26 (21): 2392-407; Nov 1 2012   NLM
[Abstract]
[DOI] [Full Text]

The structure of human argonaute-2 in complex with miR-20a
Elkayam E,
Kuhn CD,
Tocilj A,
Haase AD,
Greene EM,
Hannon GJ,
Joshua-Tor L

Cell
  150 (1): 100-10; Jul 6 2012   NLM
[Abstract]
[DOI] [Full Text]

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation
Lavy T,
Kumar PR,
He H,
Joshua-Tor L

Genes Dev
  26 (3): 294-303; Feb 1 2012   NLM
[Abstract]
[DOI] [Full Text]

The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS
Schalch T,
Job G,
Shanker S,
Partridge JF,
Joshua-Tor L

Nat Struct Mol Biol
  18 (12): 1351-7; Dec 2011   NLM
[Abstract]
[DOI] [Full Text]

Ancestral roles of small RNAs: an Ago-centric perspective
Joshua-Tor L,
Hannon GJ

Cold Spring Harb Perspect Biol
  3 (10): a003772; Oct 2011   NLM
[Abstract]
[DOI] [Full Text]

Argonaute MID domain takes centre stage
Faehnle CR,
Joshua-Tor L

EMBO Rep
  11 (8): 564-5; Aug 2010   NLM
[DOI] [Full Text]

High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin
Schalch T,
Job G,
Noffsinger VJ,
Shanker S,
Kuscu C,
Joshua-Tor L,
Partridge JF

Mol Cell
  34 (1): 36-46; Apr 10 2009   NLM
[Abstract]
[DOI] [Full Text]

On helicases and other motor proteins
Enemark EJ,
Joshua-Tor L

Curr Opin Struct Biol
  18 (2): 243-57; Apr 2008   NLM
[Abstract]
[DOI] [Full Text]

NADP regulates the yeast GAL induction system
Kumar PR,
Yu Y,
Sternglanz R,
Johnston SA,
Joshua-Tor L

Science
  319 (5866): 1090-2; Feb 22 2008   NLM
[Abstract]
[DOI] [Full Text]

Argonautes confront new small RNAs
Faehnle CR,
Joshua-Tor L

Curr Opin Chem Biol
  11 (5): 569-77; Oct 2007   NLM
[Abstract]
[DOI] [Full Text]

Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure
OFarrell PA,
Joshua-Tor L

Biochem J
  401 (2): 421-8; Jan 15 2007   NLM
[Abstract]
[DOI] [Full Text]

Slicer and the argonautes
Tolia NH,
Joshua-Tor L

Nat Chem Biol
  3 (1): 36-43; Jan 2007   NLM
[Abstract]
[DOI] [Full Text]

Argonaute slicing is required for heterochromatic silencing and spreading
Irvine DV,
Zaratiegui M,
Tolia NH,
Goto DB,
Chitwood DH,
Vaughn MW,
Joshua-Tor L,
Martienssen RA

Science
  313 (5790): 1134-7; Aug 25 2006   NLM
[Abstract]
[DOI] [Full Text]

Mechanism of DNA translocation in a replicative hexameric helicase
Enemark EJ,
Joshua-Tor L

Nature
  442 (7100): 270-5; Jul 20 2006   NLM
[Abstract]
[DOI] [Full Text]

Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
Yigit E,
Batista PJ,
Bei Y,
Pang KM,
Chen CC,
Tolia NH,
Joshua-Tor L,
Mitani S,
Simard MJ,
Mello CC

Cell
  127 (4): 747-757; 2006  
[Abstract]
[DOI] [Full Text]

Argonaute and RNA - Getting into the groove
Song JJ,
Joshua-Tor L

Current Opinion in Structural Biology
  16 (1): 5-11; 2006  
[Abstract]
[DOI] [Full Text]

The Argonautes
Joshua-Tor L

Cold Spring Harb Symp Quant Biol
  71 (0): 67-72; 2006   NLM
[Abstract]
[DOI] [Full Text]

Strategies for protein coexpression in Escherichia coli
Tolia NH,
Joshua-Tor L

Nat Methods
  3 (1): 55-64; Jan 2006   NLM
[DOI] [Full Text]

Purified Argonaute2 and an siRNA form recombinant human RISC
Rivas FV,
Tolia NH,
Song JJ,
Aragon JP,
Liu J,
Hannon GJ,
Joshua-Tor L

Nat Struct Mol Biol
  12 (4): 340-9; Apr 2005   NLM
[Abstract]
[DOI] [Full Text]

Erratum: Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum (Cell (July 29, 2005) 122 (183-193))
Tolia NH,
Enemark EJ,
Sim BK,
Joshua-Tor L

Cell
  122 (3): 485; 2005  
[DOI] [Full Text]

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum
Tolia NH,
Enemark EJ,
Sim BK,
Joshua-Tor L

Cell
  122 (2): 183-193; 2005  
[Abstract]
[DOI] [Full Text]

Crystal structure of Argonaute and its implications for RISC slicer activity
Song JJ,
Smith SK,
Hannon GJ,
Joshua-Tor L

Science
  305 (5689): 1434-7; Sep 3 2004   NLM
[Abstract]
[DOI] [Full Text]

Argonaute2 is the catalytic engine of mammalian RNAi
Liu J,
Carmell MA,
Rivas FV,
Marsden CG,
Thomson JM,
Song JJ,
Hammond SM,
Joshua-Tor L,
Hannon GJ

Science
  305 (5689): 1437-41; Sep 3 2004   NLM
[Abstract]
[DOI] [Full Text]

siRNAs at RISC
Joshua-Tor L

Structure
  12 (7): 1120-2; Jul 2004   NLM
[DOI] [Full Text]

The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding
Auster AS,
Joshua-Tor L

J Biol Chem
  279 (5): 3733-42; Jan 30 2004   NLM
[Abstract]
[DOI] [Full Text]

The Bleomycin Hydrolases
Joshua-Tor L,
Johnston SA
In:
Handbook of Proteolytic Enzymes
(eds. Barrett, A. J. Rawlings, N. D. Woessner, J. F.) : Elsevier Academic Pr; 2004. : 1197-1201  
[Full Text]

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
Song JJ,
Liu J,
Tolia NH,
Schneiderman J,
Smith SK,
Martienssen RA,
Hannon GJ,
Joshua-Tor L

Nat Struct Biol
  10 (12): 1026-32; Dec 2003   NLM
[Abstract]
[DOI] [Full Text]

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution
van Aalten DM,
Crielaard W,
Hellingwerf KJ,
Joshua-Tor L

Acta Crystallogr D Biol Crystallogr
  58 (0): 585-90; Apr 2002   NLM
[Abstract]
[DOI] [Full Text]

Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster
Messick TE,
Chmiel NH,
Golinelli MP,
Langer MR,
Joshua-Tor L,
David SS

Biochemistry
  41 (12): 3931-42; Mar 26 2002   NLM
[Abstract]
[DOI] [Full Text]

Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex
Enemark EJ,
Stenlund A,
Joshua-Tor L

EMBO J
  21 (6): 1487-96; Mar 15 2002   NLM
[Abstract]
[DOI] [Full Text]

Engineering photocycle dynamics. Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants
van Aalten DM,
Haker A,
Hendriks J,
Hellingwerf KJ,
Joshua-Tor L,
Crielaard W

J Biol Chem
  277 (8): 6463-8; Feb 22 2002   NLM
[Abstract]
[DOI] [Full Text]

Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases
Russell SJ,
Gonzalez F,
Joshua-Tor L,
Johnston SA

Chem Biol
  8 (10): 941-50; Oct 2001   NLM
[Abstract]
[DOI] [Full Text]

Participation of the iron-sulfur cluster loop (FCL) motif of the adenine glycosylase MutY in DNA damage recognition and repair
David SS,
Golinelli MP,
Chmiel NH,
Langer MR,
Chepanoske CL,
Messick TR,
Joshua-Tor L

Abstracts of Papers of the American Chemical Society
  222 (0): U578-U578; Aug 2001  
[Full Text]

Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes
van Aalten DM,
Chong CR,
Joshua-Tor L

Biochemistry
  39 (33): 10082-9; Aug 22 2000   NLM
[Abstract]
[DOI] [Full Text]

Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus
Enemark EJ,
Chen G,
Vaughn DE,
Stenlund A,
Joshua-Tor L

Mol Cell
  6 (1): 149-58; Jul 2000   NLM
[Abstract]
[DOI] [Full Text]

Conformational substates in different crystal forms of the photoactive yellow protein--correlation with theoretical and experimental flexibility
van Aalten DM,
Crielaard W,
Hellingwerf KJ,
Joshua-Tor L

Protein Sci
  9 (1): 64-72; Jan 2000   NLM
[Abstract]
[DOI] [Full Text]

A structural snapshot of base-pair opening in DNA
van Aalten DM,
Erlanson DA,
Verdine GL,
Joshua-Tor L

Proc Natl Acad Sci U S A
  96 (21): 11809-14; Oct 12 1999   NLM
[Abstract]
[DOI] [Full Text]

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
OFarrell PA,
Gonzalez F,
Zheng W,
Johnston SA,
Joshua-Tor L

Structure
  7 (6): 619-27; Jun 15 1999   NLM
[Abstract]
[DOI] [Full Text]

Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling
Vaughn DE,
Rodriguez J,
Lazebnik Y,
Joshua-Tor L

J Mol Biol
  293 (3): 439-447; 1999  
[Abstract]
[DOI] [Full Text]

Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum
Schlessman JL,
Woo D,
Joshua-Tor L,
Howard JB,
Rees DC

J Mol Biol
  280 (4): 669-85; Jul 24 1998   NLM
[Abstract]
[DOI] [Full Text]

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase
Zheng W,
Johnston SA,
Joshua-Tor L

Cell
  93 (1): 103-9; Apr 3 1998   NLM
[Abstract]
[DOI] [Full Text]

Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant
van Aalten DM,
Grotewold E,
Joshua-Tor L

Methods
  14 (3): 318-28; Mar 1998   NLM
[Abstract]
[DOI] [Full Text]

The Bleomycin Hydrolases
Joshua-Tor L,
Johnston SA
In:
Handbook of Proteolytic Enzymes
(eds. Barrett, A. J. Rawlings, N. D. Woessner, J. F.) London: Elsevier Academic Pr; 1998. : 634-638  


Crystal Structures of the Iron Protein and Molybdenum-Iron Protein of Nitrogenase
Rees DC,
Kim J,
Georgiadis MM,
Komiya H,
Chirino AJ,
Woo D,
Schlessman J,
Chan MK,
Joshua-Tor L,
Santillan G,
Chakrabarti P,
Hsu BT
In:
Molybdenum Enzymes, Cofactors, and Model Systems
(eds. Stiefl, E. I. Coucouvanis, D Newton, W. E.) : American Chemical So; 1993. 535: 170-185  
[DOI] [Full Text]

The coming of age of DNA crystallography
Joshua-Tor L,
Sussman JL

Current Opinion in Structural Biology
  3 (3): 323-335; 1993  
[Abstract]
[DOI] [Full Text]

X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus
Day MW,
Hsu BT,
Joshua-Tor L,
Park JB,
Zhou ZH,
Adams MW,
Rees DC

Protein Sci
  1 (11): 1494-507; Nov 1992   NLM
[Abstract]
[DOI] [Full Text]

Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein
Blake PR,
Day MW,
Hsu BT,
Joshua-Tor L,
Park JB,
Hare DR,
Adams MW,
Rees DC,
Summers MF

Protein Sci
  1 (11): 1522-5; Nov 1992   NLM
[Abstract]
[DOI] [Full Text]

A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis
Berman HM,
Sussman JL,
Joshua-Tor L,
Revich GG,
Ripley LS

J Biomol Struct Dyn
  10 (2): 317-31; Oct 1992   NLM
[Abstract]
[Full Text]

Three-dimensional structures of bulge-containing DNA fragments
Joshua-Tor L,
Frolow F,
Appella E,
Hope H,
Rabinovich D,
Sussman JL

J Mol Biol
  225 (2): 397-431; May 20 1992   NLM
[Abstract]
[DOI] [Full Text]

The three-dimensional structure of a DNA duplex containing looped-out bases
Joshua-Tor L,
Rabinovich D,
Hope H,
Frolow F,
Appella E,
Sussman JL

Nature
  334 (6177): 82-4; Jul 7 1988   NLM
[Abstract]
[DOI] [Full Text]

A kinked model of a DNA tridecamer with an unpaired adenosine: Energy Minimization and X-ray structural studies
Sussman JL,
Joshua-Tor L,
Hirshberg M,
Saper MA
In:
Molecular structure: chemical reactivity and biological activity
(eds. Stezowski, J.J. Jin-Ling Huang Mei-Cheng Shao International Union of Crystallography) Oxford: Oxford University Pr; 1988. : 195-200  
[Full Text]


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