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8 Article(s) on File
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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
McDermott U,
Sharma SV,
Dowell L,
Greninger P,
Montagut C,
Lamb J,
Archibald H,
Raudales R,
Tam A,
Lee D,
Rothenberg SM,
Supko JG,
Sordella R,
Ulkus LE,
Iafrate AJ,
Maheswaran S,
Njauw CN,
Tsao H,
Drew L,
Hanke JH,
Ma XJ,
Erlander MG,
Gray NS,
Haber DA,
Settleman J

Proc Natl Acad Sci U S A
  104 (50): 19936-41; Dec 11 2007   PMCID: PMC2148401
[Abstract]
[DOI]

Disrupting surfaces of Nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
Iafrate AJ,
Carl S,
Bronson S,
Stahl-Hennig C,
Swigut T,
Skowronski J,
Kirchhoff F

Journal of Virology
  74 (21): 9836-9844; Nov 2000  
[Abstract]
[Full Text] [PDF]

Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression
Swigut T,
Iafrate AJ,
Muench J,
Kirchhoff F,
Skowronski J

Journal of Virology
  74 (12): 5691-5701; Jun 2000  
[Abstract]
[Full Text]

Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques
Carl S,
Iafrate AJ,
Lang SM,
Stolte N,
Stahl-Hennig C,
Matz-Rensing K,
Fuchs D,
Skowronski J,
Kirchhoff F

Journal of Virology
  74 (9): 4155-4164; May 2000  
[Abstract]
[Full Text]

Partial repair of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection
Carl S,
Daniels R,
Iafrate AJ,
Easterbrook P,
Greenough TC,
Skowronski J,
Kirchhoff F

Journal of Infectious Diseases
  181 (1): 132-140; Jan 2000  
[Abstract]
[Full Text]

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis
Lock M,
Greenberg ME,
Iafrate AJ,
Swigut T,
Muench J,
Kirchhoff F,
Shohdy N,
Skowronski J

Embo J
  18 (10): 2722-33; May 17 1999  
[Abstract]
[Full Text]

HIV and SIV Nef modulate signal transduction and protein sorting in T cells
Skowronski J,
Greenberg ME,
Lock M,
Mariani R,
Salghetti S,
Swigut T,
Iafrate AJ

Cold Spring Harb Symp Quant Biol
  64 (0): 453-63; 1999  
[Full Text]

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
Greenberg ME,
Iafrate AJ,
Skowronski J

Embo J
  17 (10): 2777-89; May 15 1998  
[Abstract]
[Full Text]


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