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265 Article(s) on File
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A Computational Algorithm to Predict shRNA Potency
Knott SR,
Maceli AR,
Erard N,
Chang K,
Marran K,
Zhou X,
Gordon A,
El Demerdash O,
Wagenblast E,
Kim S,
Fellmann C,
Hannon GJ

Mol Cell
  (0): Nov 25 2014   Nlm
[Abstract]
[DOI] [Full Text]

microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development
Deng L,
Shang L,
Bai S,
Chen J,
He X,
Trevino RM,
Chen S,
Li X,
Meng X,
Yu B,
Wang X,
Liu Y,
McDermott SP,
Ariazi AE,
Ginestier C,
Ibarra I,
Ke J,
Luther TK,
Clouthier SG,
Xu L,
Shan G,
Song E,
Yao H,
Hannon GJ,
Weiss SJ,
Wicha MS,
Liu S

Cancer Research
  74 (22): 6648-6660; Nov 15 2014   Nlm
[Abstract]
[DOI] [Full Text]

Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence
Yang M,
Haase AD,
Huang FK,
Coulis G,
Rivera KD,
Dickinson BC,
Chang CJ,
Pappin DJ,
Neubert TA,
Hannon GJ,
Boivin B,
Tonks NK

Molecular Cell
  55 (5): 782-790; Aug 27 2014   Nlm
[Abstract]
[DOI] [Full Text]

A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity
Fagegaltier D,
Konig A,
Gordon A,
Lai EC,
Gingeras TR,
Hannon GJ,
Shcherbata HR

Genetics
  198 (2): 647-668; Jul 31 2014   Nlm
[Abstract]
[DOI] [Full Text]

Two waves of de novo methylation during mouse germ cell development
Molaro A,
Falciatori I,
Hodges E,
Aravin AA,
Marran K,
Rafii S,
McCombie WR,
Smith AD,
Hannon GJ

Genes Dev
  28 (14): 1544-9; Jul 15 2014   Nlm
[Abstract]
[DOI] [Full Text]

A genome-wide RNAi screen identifies factors required for distinct stages of C-elegans piRNA biogenesis
Goh WS,
Seah JW,
Harrison EJ,
Chen C,
Hammell CM,
Hannon GJ

Genes Development
  28 (7): 797-807; Apr 2014  
[Abstract]
[DOI] [Full Text]

An atlas of chromatoid body components
Meikar O,
Vagin VV,
Chalmel F,
Sostar K,
Lardenois A,
Hammell M,
Jin Y,
Da Ros M,
Wasik KA,
Toppari J,
Hannon GJ,
Kotaja N

RNA
  20 (4): 483-95; Apr 2014   NLM
[Abstract]
[DOI] [Full Text]

Slicer and the Argonautes
Faehnle CR,
Elkayam E,
Haase AD,
Hannon GJ,
Joshua-Tor L

Biophysical Journal
  106 (2): 455A-455A; Jan 28 2014   Thomson-Reuters
[Abstract]
[DOI] [Full Text]

Patient-derived tumor xenografts: Transforming clinical samples into mouse models
Siolas D,
Hannon GJ

Cancer Research
  73 (17): 5315-5319; Sep 2013   NLM
[Abstract]
[DOI] [Full Text]

Minotaur is critical for primary piRNA biogenesis
Vagin VV,
Yu Y,
Jankowska A,
Luo Y,
Wasik KA,
Malone CD,
Harrison E,
Rosebrock A,
Wakimoto BT,
Fagegaltier D,
Muerdter F,
Hannon GJ

RNA
  19 (8): 1064-1077; Aug 20 2013   NLM
[Abstract]
[DOI] [Full Text]

A Genomic-Scale Artificial MicroRNA Library as a Tool to Investigate the Functionally Redundant Gene Space in Arabidopsis
Hauser F,
Chen WX,
Deinlein U,
Chang K,
Ossowski S,
Fitz J,
Hannon GJ,
Schroeder JI

Plant Cell
  25 (8): 2848-2863; Aug 1 2013   NLM
[Abstract]
[DOI] [Full Text]

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma
Wiggs JL,
Howell GR,
Linkroum K,
Abdrabou W,
Hodges E,
Braine CE,
Pasquale LR,
Hannon GJ,
Haines JL,
John SW

Clinical Genetics
  84 (2): 167; Aug 2013   NLM
[DOI] [Full Text]

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates
Karginov FV,
Hannon GJ

Genes Dev
  27 (14): 1624-1632; Jul 15 2013   NLM
[Abstract]
[DOI] [Full Text]

De novo DNA demethylation and non-coding transcription define active intergenic regulatory elements
Schlesinger F,
Smith AD,
Gingeras TR,
Hannon GJ,
Hodges E

Genome Res
  23 (10): 1601-1614; Jun 28 2013   NLM
[Abstract]
[DOI] [Full Text]

A Genome-wide RNAi Screen Draws a Genetic Framework for Transposon Control and Primary piRNA Biogenesis in Drosophila
Muerdter F,
Guzzardo PM,
Gillis J,
Luo Y,
Yu Y,
Chen C,
Fekete R,
Hannon G

Molecular Cell
  50 (5): 736-748; Jun 6 2013   Elsevier
[Abstract]
[DOI] [Full Text]

Dnmt2-dependent methylomes lack defined DNA methylation patterns
Raddatz G,
Guzzardo PM,
Olova N,
Fantappié MR,
Rampp M,
Schaefer M,
Reik W,
Hannon GJ,
Lyko F

Proceedings of the National Academy of Sciences of the United States of America
  110 (21): 8627-8631; May 21 2013  
[DOI] [Full Text]

Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells
Dos Santos CO,
Rebbeck C,
Rozhkova E,
Valentine A,
Samuels A,
Kadiri LR,
Osten P,
Harris EY,
Uren PJ,
Smith AD,
Hannon GJ

Proc Natl Acad Sci U S A
  110 (18): 7123-7130; Apr 20 2013   NLM
[Abstract]
[DOI] [Full Text]

Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9
Lu XW,
Wontakal SN,
Kavi H,
Kim BJ,
Guzzardo PM,
Emelyanov AV,
Xu N,
Hannon GJ,
Zavadil J,
Fyodorov DV,
Skoultchi AI

Science
  340 (6128): 78-81; Apr 2013   TR
[Abstract]
[DOI] [Full Text]

Dogma derailed: the many influences of RNA on the genome
Sabin LR,
Delas MJ,
Hannon GJ

Mol Cell
  49 (5): 783-94; Mar 7 2013   Nlm
[Abstract]
[DOI] [Full Text]

Multiple roles for Piwi in silencing Drosophila transposons
Rozhkov NV,
Hammell M,
Hannon GJ

Genes and Development
  27 (4): 400-412; Feb 15 2013  
[Abstract]
[DOI] [Full Text]

Dicer-2 Processes Diverse Viral RNA Species
Sabin LR,
Zheng Q,
Thekkat P,
Yang J,
Hannon GJ,
Gregory BD,
Tudor M,
Cherry S

PLoS ONE
  8 (2): art. no e55458; Feb 12 2013  
[Abstract]
[DOI] [Full Text]

The piRNA pathway in flies: highlights and future directions
Guzzardo PM,
Muerdter F,
Hannon GJ

Curr Opin Genet Dev
  23 (1): 44-52; Jan 11 2013   NLM
[Abstract]
[DOI] [Full Text]

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus
Kaaij LT,
van de Wetering M,
Fang F,
Decato B,
Molaro A,
van de Werken HJ,
van Es JH,
Schuijers J,
de Wit E,
de Laat W,
Hannon GJ,
Clevers HC,
Smith AD,
Ketting RF

Genome Biology
  14 (5): 2013   NLM
[Abstract]
[DOI] [Full Text]

Site identification in high-throughput RNA-protein interaction data
Uren PJ,
Bahrami-Samani E,
Burns SC,
Qiao M,
Karginov FV,
Hodges E,
Hannon GJ,
Sanford JR,
Penalva LO,
Smith AD

Bioinformatics
  28 (23): 3013-3120; Dec 1 2012   NLM
[Abstract]
[DOI] [Full Text]

Inducing RNAi in C. elegans by Feeding with dsRNA-expressing E. coli
Hammell CM,
Hannon GJ

Cold Spring Harb Protoc
  2012 (12): Dec 1 2012   NLM
[Abstract]
[DOI] [Full Text]

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
Ipsaro JJ,
Haase AD,
Knott SR,
Joshua-Tor L,
Hannon GJ

Nature
  491 (7423): 279-83; Nov 8 2012   NLM
[Abstract]
[DOI] [Full Text]

Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Dow L,
Lowe S,
Zuber J,
Hannon G

European Journal of Cancer
  48 (0): 16-16; Nov 6 2012  
[Full Text]

Unique small RNA signatures uncovered in the tammar wallaby genome
Lindsay J,
Carone DM,
Brown J,
Hall L,
Qureshi S,
Mitchell SE,
Jannetty N,
Hannon G,
Renfree M,
Pask A,
ONeill M,
ONeill R

BMC Genomics
  13 (0): Oct 17 2012  
[Abstract]
[DOI] [Full Text]

Extreme Telomere Length Dimorphism in the Tasmanian Devil and Related Marsupials Suggests Parental Control of Telomere Length
Bender HS,
Murchison EP,
Pickett HA,
Deakin JE,
Strong MA,
Conlan C,
McMillan DA,
Neumann AA,
Greider CW,
Hannon GJ,
Reddel RR,
Graves JA

PLoS ONE
  7 (9): e46195; Sep 25 2012  
[Abstract]
[DOI] [Full Text]

An integrated encyclopedia of DNA elements in the human genome
Dunham I,
Kundaje A,
Aldred SF,
Collins PJ,
Davis C,
Doyle F,
Epstein CB,
Frietze S,
Harrow J,
Kaul R,
Khatun J,
Lajoie BR,
Landt SG,
Lee BK,
Pauli F,
Rosenbloom KR,
Sabo P,
Safi A,
Sanyal A,
Shoresh N,
Simon JM,
Song L,
Trinklein ND,
Altshuler RC,
Birney E,
Brown JB,
Cheng C,
Djebali S,
Dong XJ,
Ernst J,
Furey TS,
Gerstein M,
Giardine B,
Greven M,
Hardison RC,
Harris RS,
Herrero J,
Hoffman MM,
Iyer S,
Kellis M,
Kheradpour P,
Lassmann T,
Li QH,
Lin X,
Marinov GK,
Merkel A,
Mortazavi A,
Parker SC,
Reddy TE,
Rozowsky J,
Schlesinger F,
Thurman RE,
Wang J,
Ward LD,
Whitfield TW,
Wilder SP,
Wu W,
Xi HL,
Yip KY,
Zhuang JL,
Bernstein BE,
Green ED,
Gunter C,
Snyder M,
Pazin MJ,
Lowdon RF,
Dillon LA,
Adams LB,
Kelly CJ,
Zhang J,
Wexler JR,
Good PJ,
Feingold EA,
Crawford GE,
Dekker J,
Elnitski L,
Farnham PJ,
Giddings MC,
Gingeras TR,
Guigo R,
Hubbard TJ,
Kent WJ,
Lieb JD,
Margulies EH,
Myers RM,
Stamatoyannopoulos JA,
Tenenbaum SA,
Weng ZP,
White KP,
Wold B,
Yu Y,
Wrobel J,
Risk BA,
Gunawardena HP,
Kuiper HC,
Maier CW,
Xie L,
Chen X,
Mikkelsen TS,
Gillespie S,
Goren A,
Ram O,
Zhang XL,
Wang L,
Issner R,
Coyne MJ,
Durham T,
Ku M,
Truong T,
Eaton ML,
Davis CA,
Dobin A,
Tanzer A,
Lagarde J,
Lin W,
Xue CH,
Williams BA,
Zaleski C,
Roeder M,
Kokocinski F,
Abdelhamid RF,
Alioto T,
Antoshechkin I,
Baer MT,
Batut P,
Bell I,
Bell K,
Chakrabortty S,
Chrast J,
Curado J,
Derrien T,
Drenkow J,
Dumais E,
Dumais J,
Duttagupta R,
Fastuca M,
Fejes-Toth K,
Ferreira P,
Foissac S,
Fullwood MJ,
Gao H,
Gonzalez D,
Gordon A,
Howald C,
Jha S,
Johnson R,
Kapranov P,
King B,
Kingswood C,
Li GL,
Luo OJ,
Park E,
Preall JB,
Presaud K,
Ribeca P,
Robyr D,
Ruan XA,
Sammeth M,
Sandhu KS,
Schaeffer L,
See LH,
Shahab A,
Skancke J,
Suzuki AM,
Takahashi H,
Tilgner H,
Trout D,
Walters N,
Wang HE,
Yu YB,
Hayashizaki Y,
Reymond A,
Antonarakis SE,
Hannon GJ,
Ruan YJ,
Carninci P,
Sloan CA,
Learned K,
Malladi VS,
Wong MC,
Barber G,
Cline MS,
Dreszer TR,
Heitner SG,
Karolchik D,
Kirkup VM,
Meyer LR,
Long JC,
Maddren M,
Raney BJ,
Song LY,
Grasfeder LL,
Giresi PG,
Battenhouse A,
Sheffield NC,
Showers KA,
London D,
Bhinge AA,
Shestak C,
Schaner MR,
Kim SK,
Zhang ZZ,
Mieczkowski PA,
Mieczkowska JO,
Liu Z,
McDaniell RM,
Ni YY,
Rashid NU,
Kim MJ,
Adar S,
Zhang ZC,
Wang TY,
Winter D,
Keefe D,
Iyer VR,
Zheng MZ,
Wang P,
Gertz J,
Vielmetter J,
Partridge EC,
Varley KE,
Gasper C,
Bansal A,
Pepke S,
Jain P,
Amrhein H,
Bowling KM,
Anaya M,
Cross MK,
Muratet MA,
Newberry KM,
McCue K,
Nesmith AS,
Fisher-Aylor KI,
Pusey B,
DeSalvo G,
Parker SL,
Balasubramanian S,
Davis NS,
Meadows SK,
Eggleston T,
Newberry JS,
Levy SE,
Absher DM,
Wong WH,
Blow MJ,
Visel A,
Pennachio LA,
Petrykowska HM,
Abyzov A,
Aken B,
Barrell D,
Barson G,
Berry A,
Bignell A,
Boychenko V,
Bussotti G,
Davidson C,
Despacio-Reyes G,
Diekhans M,
Ezkurdia I,
Frankish A,
Gilbert J,
Gonzalez JM,
Griffiths E,
Harte R,
Hendrix DA,
Hunt T,
Jungreis I,
Kay M,
Khurana E,
Leng J,
Lin MF,
Loveland J,
Lu Z,
Manthravadi D,
Mariotti M,
Mudge J,
Mukherjee G,
Notredame C,
Pei BK,
Rodriguez JM,
Saunders G,
Sboner A,
Searle S,
Sisu C,
Snow C,
Steward C,
Tapanari E,
Tress ML,
van Baren MJ,
Washietl S,
Wilming L,
Zadissa A,
Zhang ZD,
Brent M,
Haussler D,
Valencia A,
Addleman N,
Alexander RP,
Auerbach RK,
Bettinger K,
Bhardwaj N,
Boyle AP,
Cao AR,
Cayting P,
Charos A,
Cheng Y,
Eastman C,
Euskirchen G,
Fleming JD,
Grubert F,
Habegger L,
Hariharan M,
Harmanci A,
Iyengar S,
Jin VX,
Karczewski KJ,
Kasowski M,
Lacroute P,
Lam H,
Lamarre-Vincent N,
Lian J,
Lindahl-Allen M,
Min RQ,
Miotto B,
Monahan H,
Moqtaderi Z,
Mu XM,
OGeen H,
Ouyang ZQ,
Patacsil D,
Raha D,
Ramirez L,
Reed B,
Shi MY,
Slifer T,
Witt H,
Wu LF,
Xu XQ,
Yan KK,
Yang XQ,
Struhl K,
Weissman SM,
Penalva LO,
Karmakar S,
Bhanvadia RR,
Choudhury A,
Domanus M,
Ma LJ,
Moran J,
Victorsen A,
Auer T,
Centanin L,
Eichenlaub M,
Gruhl F,
Heermann S,
Hoeckendorf B,
Inoue D,
Kellner T,
Kirchmaier S,
Mueller C,
Reinhardt R,
Schertel L,
Schneider S,
Sinn R,
Wittbrodt B,
Wittbrodt J,
Jain G,
Balasundaram G,
Bates DL,
Byron R,
Canfield TK,
Diegel MJ,
Dunn D,
Ebersol AK,
Frum T,
Garg K,
Gist E,
Hansen RS,
Boatman L,
Haugen E,
Humbert R,
Johnson AK,
Johnson EM,
Kutyavin TV,
Lee K,
Lotakis D,
Maurano MT,
Neph SJ,
Neri FV,
Nguyen ED,
Qu HZ,
Reynolds AP,
Roach V,
Rynes E,
Sanchez ME,
Sandstrom RS,
Shafer AO,
Stergachis AB,
Thomas S,
Vernot B,
Vierstra J,
Vong S,
Wang H,
Weaver MA,
Yan YQ,
Zhang MH,
Akey JM,
Bender M,
Dorschner MO,
Groudine M,
MacCoss MJ,
Navas P,
Stamatoyannopoulos G,
Beal K,
Brazma A,
Flicek P,
Johnson N,
Lukk M,
Luscombe NM,
Sobral D,
Vaquerizas JM,
Batzoglou S,
Sidow A,
Hussami N,
Kyriazopoulou-Panagi S,
Libbrecht MW,
Schaub MA,
Miller W,
Bickel PJ,
Banfai B,
Boley NP,
Huang HY,
Li JJ,
Noble WS,
Bilmes JA,
Buske OJ,
Sahu AD,
Kharchenko PV,
Park PJ,
Baker D,
Taylor J,
Lin XY,
Lochovsky L,
Min R,
Encode Project Conso

Nature
  489 (7414): 57-74; Sep 6 2012  
[Abstract]
[DOI] [Full Text]

Landscape of transcription in human cells
Djebali S,
Davis CA,
Merkel A,
Dobin A,
Lassmann T,
Mortazavi A,
Tanzer A,
Lagarde J,
Lin W,
Schlesinger F,
Xue C,
Marinov GK,
Khatun J,
Williams BA,
Zaleski C,
Rozowsky J,
Röder M,
Kokocinski F,
Abdelhamid RF,
Alioto T,
Antoshechkin I,
Baer MT,
Bar NS,
Batut P,
Bell K,
Bell I,
Chakrabortty S,
Chen X,
Chrast J,
Curado J,
Derrien T,
Drenkow J,
Dumais E,
Dumais J,
Duttagupta R,
Falconnet E,
Fastuca M,
Fejes-Toth K,
Ferreira P,
Foissac S,
Fullwood MJ,
Gao H,
Gonzalez D,
Gordon A,
Gunawardena H,
Howald C,
Jha S,
Johnson R,
Kapranov P,
King B,
Kingswood C,
Luo OJ,
Park E,
Persaud K,
Preall JB,
Ribeca P,
Risk B,
Robyr D,
Sammeth M,
Schaffer L,
See LH,
Shahab A,
Skancke J,
Suzuki AM,
Takahashi H,
Tilgner H,
Trout D,
Walters N,
Wang H,
Wrobel J,
Yu Y,
Ruan X,
Hayashizaki Y,
Harrow J,
Gerstein M,
Hubbard T,
Reymond A,
Antonarakis SE,
Hannon G,
Giddings MC,
Ruan Y,
Wold B,
Carninci P,
Guig R,
Gingeras TR

Nature
  489 (7414): 101-108; Sep 6 2012  
[Abstract]
[Full Text]

Shutdown is a component of the Drosophila piRNA biogenesis machinery
Preall JB,
Czech B,
Guzzardo PM,
Muerdter F,
Hannon GJ

RNA
  18 (8): 1446-57; Aug 2012   Nlm
[Abstract]
[DOI] [Full Text]

The structure of human argonaute-2 in complex with miR-20a
Elkayam E,
Kuhn CD,
Tocilj A,
Haase AD,
Greene EM,
Hannon GJ,
Joshua-Tor L

Cell
  150 (1): 100-10; Jul 6 2012   NLM
[Abstract]
[DOI] [Full Text]

Proffered Paper: Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Hannon GJ,
Lowe SW,
Zuber J,
Elledge S

European Journal of Cancer
  48 (0): S14-S14; Jul 2012  
[Full Text]

MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells
Liu S,
Patel SH,
Ginestier C,
Ibarra I,
Martin-Trevino R,
Bai S,
McDermott SP,
Shang L,
Ke J,
Ou SJ,
Heath A,
Zhang KJ,
Korkaya H,
Clouthier SG,
Charafe-Jauffret E,
Birnbaum D,
Hannon GJ,
Wicha MS

PLoS Genetics
  8 (6): e1002751; Jun 2012   Nlm
[Abstract]
[DOI] [Full Text]

Genomic landscape of human allele-specific DNA methylation
Fang F,
Hodges E,
Molaro A,
Dean M,
Hannon GJ,
Smith AD

Proceedings of the National Academy of Sciences of the United States of America
  109 (19): 7332-7337; May 2012  
[Abstract]
[DOI] [Full Text]

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection
Van Stry M,
Oguin TH,
Cheloufi S,
Vogel P,
Watanabe M,
Pillai MR,
Dash P,
Thomas PG,
Hannon GJ,
Bix M

Journal of Virology
  86 (15): 8344-8345; Apr 2012  
[DOI] [Full Text]

Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening
Dahlman KB,
Parker JS,
Shamu T,
Hieronymus H,
Chapinski C,
Carver B,
Chang K,
Hannon GJ,
Sawyers CL

PLoS ONE
  7 (4): Apr 11 2012  
[Abstract]
[DOI] [Full Text]

Production of transgenic calves expressing an shRNA targeting myostatin
Tessanne K,
Golding MC,
Long CR,
Peoples MD,
Hannon G,
Westhusin ME

Molecular Reproduction and Development
  79 (3): 176-185; Mar 2012  
[Abstract]
[DOI] [Full Text]

An alternative mode of microRNA target recognition
Chi SW,
Hannon GJ,
Darnell RB

Nat Struct Mol Biol
  19 (3): 321-327; Mar 2012   NLM
[Abstract]
[DOI] [Full Text]

A pipeline for the generation of shRNA transgenic mice
Dow LE,
Premsrirut PK,
Zuber J,
Fellmann C,
McJunkin K,
Miething C,
Park Y,
Dickins RA,
Hannon GJ,
Lowe SW

Nat Protoc
  7 (2): 374-93; Feb 2 2012   NLM
[Abstract]
[DOI] [Full Text]

Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He M,
Liu Y,
Wang X,
Zhang MQ,
Hannon GJ,
Huang ZJ

Neuron
  73 (1): 35-48; Jan 12 2012   NLM
[Abstract]
[DOI] [Full Text]

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy
Tan X,
Lu ZJ,
Gao G,
Xu QK,
Hu L,
Fellmann C,
Li MZ,
Qu HJ,
Lowe SW,
Hannon GJ,
Elledge SJ

Proceedings of the National Academy of Sciences of the United States of America
  109 (3): 869-874; Jan 2012  
[Abstract]
[DOI] [Full Text]

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